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IL1A — TNFRSF11B

Text-mined interactions from Literome

Sakata et al., J Bone Miner Res 1999 : After 12 h of treatment, IL-1beta at 3 ng/ml and TNF-alpha at 3 ng/ml increased OPG/OCIF mRNA expression by 190 % and 110 %, respectively, with a maximal effect
Brändström et al., Biochem Biophys Res Commun 2001 : Using this ELISA, the amount of OPG secreted from human bone marrow stromal cells was clearly detectable, and the secretion of OPG-protein was potently regulated by prostaglandin E ( 2 ), forskolin, phorbol 12,13 di butyrate, IL-1 alpha , TNF-alpha, and dexamethasone
Fukushima et al., Bone 2005 : IL-1alpha up-regulated receptor activator of NF-kappaB ligand ( RANKL ) and down-regulated osteoprotegerin (OPG) mRNA expression in PDL cells ... In contrast, NEMO binding domain (NBD) peptide, a specific inhibitor of NF-kappaB signaling, did not affect COX2, RANKL, or OPG mRNA expression induced by IL-1alpha
Tanabe et al., Life Sci 2005 : We examined the effect of the inflammatory mediator IL-1alpha on the expression of macrophage colony stimulating factor ( M-CSF ), osteoprotegerin (OPG), and prostaglandin E2 ( PGE2 ) in rat osteoblasts, and the indirect effect of IL-1alpha on the formation of osteoclast-like cells
Hormdee et al., Clin Exp Immunol 2005 : The aim of the present study was to investigate the regulatory effects of IL-1 on RANKL and OPG production by mesenchymal fibroblasts in periodontal tissue ... In HGF, IL-1alpha stimulated OPG mRNA expression was high and could be reduced by CHX ... PKA inhibitor completely abrogated IL-1alpha induced OPG mRNA expression and OPG production ... Endogenous PGE ( 2 ) further enhanced IL-1alpha induced OPG production in HGF ... IL-1alpha induced OPG mRNA expression and protein production ... PKC inhibitor partially reduced IL-1alpha induced OPG production and PKC activator enhanced OPG production in PDL ... The IL-1alpha stimulated OPG mRNA expression in HGF was greater than PDL
Ben-Tal Cohen et al., Biochem Pharmacol 2007 : Atorvastatin also downregulated interleukin-1alpha (IL-1alpha) induced OPG production in endothelial cells
Dovio et al., J Steroid Biochem Mol Biol 2009 (Prostatic Neoplasms) : In PC-3 cells, IL-1beta stimulated IL-6 and OPG release, and dexamethasone dose-dependently inhibited IL-1beta-inducible IL-6 release, and constitutive and IL-1beta-inducible OPG release
Rachner et al., J Cell Biochem 2009 (Breast Neoplasms) : In both cells, OPG mRNA levels and protein secretion were dose- and time-dependently enhanced by interleukin (IL)-1beta and suppressed by dexamethasone
Suda et al., Oral Microbiol Immunol 2009 : The siRNA for beta-catenin suppressed the IL-1alpha induced OPG production in both PDL cells and hGFs, whereas the AP-1 inhibitor curcumin augmented the IL-1alpha induced OPG production in PDL cells, but not in hGFs ... The present study suggests that beta-catenin enhances IL-1alpha induced OPG production in both PDL cells and hGFs, whereas AP-1 suppresses IL-1alpha induced OPG production in PDL cells
Tipton et al., J Periodontal Res 2011 (Necrosis) : BPs generally further increased the production of LPS- or IL-1ß stimulated IL-6 ( p = 0.04 ) and had no effect on, or further increased, the production of LPS- or IL-1ß stimulated OPG ( p = 0.04 )
Lee et al., Arthritis Res Ther 2011 (Arthritis, Gouty...) : MSU crystals induced the expressions of IL-1 , IL-6, TNF-alpha and RANKL in PBMCs, but inhibited OPG expression
Diercke et al., J Orofac Orthop 2012 (Mechanotransduction, Cellular) : Stimulation with IL-1ß induced RANKL and OPG expression
Lazzerini et al., Joint Bone Spine 2013 (Bone Resorption...) : The effect of rosuvastatin±IL-1ß on the anti-resorptive molecule osteoprotegerin (OPG) was also assessed ( ELISA )
Vidal et al., Biochem Biophys Res Commun 1998 (Bone Neoplasms...) : Time-course studies show that IL-1 alpha ( 25 U/ml ) causes a transient increase of OPG mRNA levels in MG-63 cells, peaking after 4 h of treatment ... In MG-63 cells neither basal-nor IL-1 alpha induced OPG mRNA levels are altered by the translational inhibitor cycloheximide ... These results suggest that expression of OPG in osteoblasts may be regulated by IL-1 alpha
Hofbauer et al., Biochem Biophys Res Commun 1998 : Interleukin (IL)-1beta ( 5 x 10 ( -9 ) M ), tumor necrosis factor (TNF)-alpha ( 9 x 10 ( -9 ) M ), and bone morphogenetic protein (BMP)-2 ( 100 ng/ml ) also increased OPG mRNA levels in hFOB cells by 4-, 6-, and 4-fold, respectively