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IL2 — PPARG

Pathways - manually collected, often from reviews:

• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: NFAT1-c-4/PPARG complex (NFATC1_NFATC2_NFATC3-PPARG) → IL2 (IL2) (transcription, inhibits) Yang et al., J Biol Chem 2000
  Evidence: reporter gene

Text-mined interactions from Literome

Yang et al., J Biol Chem 2000 : Here we show that PPARgamma ligands, troglitazone and 15-deoxy-Delta ( 12,14 ) prostaglandin J ( 2 ), but not PPARalpha agonist Wy14643, inhibited IL-2 production and phytohemagglutinin-inducible proliferation in human peripheral blood T-cells in a dose dependent manner
Rockwell et al., Mol Pharmacol 2006 : Consequently, the putative role of PPARgamma in IL-2 suppression by 2-AG and 2-AG ether was examined in Jurkat T cells
Spelman et al., Int Immunopharmacol 2009 : Role for PPARgamma in IL-2 inhibition in T cells by Echinacea derived undeca-2E-ene-8,10-diynoic acid isobutylamide ... These experiments demonstrate that PPARgamma is involved in T cell IL-2 inhibition by undeca-2-ene-8,10-diynoic acid and suggest that cytokine modulation by the alkylamides is due to polyvalent activity