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APOA1 — SP1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Zheng et al., J Biol Chem 2001
(MAP Kinase Signaling System) :
In summary, EGF stimulation of
apoA-I expression is mediated solely by the Ras-MAP kinase cascade and enhanced activity of this pathway
requires Sp1 with an intact phosphorylation site at Thr ( 266 )
Haas et al., Metabolism 2004
(Carcinoma, Hepatocellular) :
Induction of the
apolipoprotein AI promoter by
Sp1 is repressed by saturated fatty acids ... Treatment of cells with 3 saturated fatty acids, stearic, myristic, and palmitic acid, repressed the ability of exogenous
Sp1 to
induce apo AI reporter gene expression ( 15.2 % +/- 1.7 %, 22.5 % +/- 0.3 %, 22.9 % +/- 0.1 %, 23.5 % +/- 0.8 %, respectively, P < .05 ) ... Unsaturated fatty acids, oleic, linoleic, or linolenic acid had no effect on
Sp1 mediated induction of the
apo AI promoter ... Therefore, saturated fatty acids blunt
Sp1 induction of
apo AI promoter probably at a step beyond DNA binding
Oleaga et al., Mol Nutr Food Res 2013
:
Incubation with 3-methyl-epicatechin led to an increase in HNF-3ß mRNA, HNF-3ß, ER-a, Sp1, and NFY protein levels and the activation of
ApoAI transcription
mediated by NFY,
Sp1 , and ER-a