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CXCL12 — DPP4
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
De La Luz Sierra et al., Blood 2004
:
CD26/dipeptidyl peptidase is
responsible for serum cleavage of
SDF-1alpha and SDF-1beta at the NH2 terminus
Bonig et al., Exp Hematol 2007
:
Enhanced
SDF-1 dependent chemotaxis and low
CD26 expression on MPB HPC were identified as potential contributing factors
Campbell et al., Frontiers in bioscience : a journal and virtual library 2008
:
Recent studies have shown that the inhibition of cell-surface
CD26 peptidase activity on hematopoietic stem/progenitor cell ( HSC/HPC ) populations
increases their
SDF-1/CXCL12 directed chemotaxis in vitro, and in vivo homing and engraftment
Ospelt et al., Arthritis Rheum 2010
(Arthritis, Rheumatoid...) :
Inhibition of serine protease activity of FAP and
DPP-4/CD26 in vitro
led to increased levels of
SDF-1 in concert with MMP-1 and MMP-3, which are downstream effectors of SDF-1 signaling
Christopherson et al., Exp Hematol 2012
:
A current approach under investigation involves treatment of donor cells with inhibitors that target the protease
CD26 , a negative
regulator of the chemokine
CXCL12/stromal cell derived factor-1
Takekoshi et al., Mol Cancer Ther 2012
(Lung Neoplasms...) :
In vitro analysis of amino-terminal cleavage by enzymes
dipeptidylpeptidase IV ( DPPIV/CD26 ) and matrix metalloproteinase-2 (MMP-2)
resulted in 25-fold and 2-fold slower degradation rates, respectively, of
CXCL122 compared with wtCXCL12
Fadini et al., Basic Res Cardiol 2013
(Cardiovascular Diseases...) :
High activity of
DPP-4 , a
regulator of the mobilizing chemokine
SDF-1a , was associated with altered stem cell compartmentalization
Eriksson et al., Scand J Rheumatol 2013
(Arthritis, Rheumatoid) :
Two weeks after infliximab infusion,
CXCL10/IP-10 , CCL2/MCP-1, and CCL4/MIP-1ß had decreased significantly ( p = 0.005, 0.037, and 0.028, respectively ), and after 30 weeks of treatment, soluble
CD26 was significantly
increased ( p = 0.050 )
Li et al., Molecular vision 2013
(Choroidal Neovascularization) :
Furthermore, imidapril increased SDF-1 concentrations in the peripheral circulation via
CD26 induced degradation of
SDF-1 in the bone marrow, an effect that coincided with elevated numbers of circulating EPCs
Shioda et al., Proc Natl Acad Sci U S A 1998
(HIV Infections) :
These data suggest that
CD26 mediated cleavage of
SDF-1alpha and SDF-1beta likely occurs in human bodies and promotes HIV-1 replication and disease progression