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CXCL12 — PLAU

Text-mined interactions from Literome

Hsu et al., J Cell Physiol 2012 (Carcinoma, Hepatocellular...) : SK-Hep-1 cells stimulation with uPA induced increases in the expression and secretion of SDF-1 ... By using specific inhibitors and small interfering RNA, we have demonstrated that the activation of extracellular signal related kinase ( ERK ) and c-Jun-NH ( 2 ) -terminal kinase ( JNK ) pathways are critical for uPA induced SDF-1 expression ... Inhibition of Sp1 and AP-1 activations by specific siRNAs blocked the uPA induced SDF-1 promoter activity and expression ... The effect of uPA on SK-Hep-1 signaling and SDF-1 expression is mediated by uPAR
Dar et al., Leukemia 2011 : Additionally, ROS inhibition reduced AMD3100 induced SDF-1 release, activation of circulating uPA and mobilization of progenitor cells
Huang et al., J Cell Physiol 2012 (Colorectal Neoplasms...) : We found that SDF-1 stimulation led to an increase in the expression and secretion of uPA in these cells ... Experiments involving specific inhibitors and small interfering RNA demonstrated that the activation of p38 mitogen activated protein kinase ( MAPK ) and phosphatidylinositol 3-kinase (PI3K)/Akt pathways are critical for SDF-1 induced uPA expression ... Inhibition of Sp1 and AP-1 activation blocked the SDF-1 induced expression and activity of the uPA promoter ... The effect of SDF-1 on DLD-1 signaling and uPA expression was mediated by the CXCR4/ß1 integrin axis