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CDK4 — EPHB2

Text-mined interactions from Literome

Wagner et al., Genes Dev 2001 (Disease Models, Animal...) : Activation of Ras and Erk causes induction of cyclin D1-Cdk4 without increase of cyclin E or PCNA in ductal lesions
Alldridge et al., Exp Cell Res 2003 (MAP Kinase Signaling System) : Moreover, ANXA1 reduces proliferation by ERK mediated disruption of the actin cytoskeleton and ablation of cyclin D1 protein expression and not by ERK mediated induction of the cyclin dependent kinase , CDK2, inhibitor p21 ( cip/waf )
Marzec et al., Oncogene 2007 (MAP Kinase Signaling System) : The U0126 mediated inhibition of ERK1/2 activation impaired proliferation and viability of the ALK+ TCL cells and expression of antiapoptotic factor Bcl-xL and cell cycle promoting CDK4 and phospho-RB
Saito et al., J Exp Med 2010 (Cell Transformation, Neoplastic...) : In nonpolarized epithelial cells, Erk activation results in oncogenic stress, up-regulation of the p21 ( Waf1/Cip1 ) cyclin dependent kinase inhibitor, and induction of senescence
Hong et al., Exp Cell Res 2011 (Prostatic Neoplasms) : Ectopic expression of a constitutively active AR inhibited Raf/MEK/ERK mediated regulation of the differentiation markers, neuron-specific enolase and neutral endopeptidase, and the cyclin dependent kinase inhibitors, p16(INK4A) and p21 ( CIP1 ), but not Rb phosphorylation and E2F1 expression, indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling