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EPHB2 — P2RY2

Text-mined interactions from Literome

Santiago-Pérez et al., J Cell Physiol 2001 (MAP Kinase Signaling System) : Our results indicate that calcium mobilization and ERK1/2 phosphorylation induced by P2Y(2) receptor activation are independent events in U937 monocytes
Elia et al., Cell Signal 2005 : Effects of extracellular nucleotides in the thyroid : P2Y2 receptor mediated ERK1/2 activation and c-Fos induction in PC Cl3 cells ... The P2Y2 stimulated ERK1/2 phosphorylation was : ( a ) completely blocked by PD098059, a mitogen activated protein kinase ( MEK ) inhibitor or by W-7, a Ca2+-calmodulin (CaM) antagonist ; ( b ) reduced by GF109203X, inhibitor of PKCs, or AG1478, inhibitor of EGFR tyrosine kinase, or LY294002/wortmannin, inhibitors of phosphoinositide 3-kinases, or cytochalasin D, inhibitor of actin microfilament bundles polymerization ... In conclusion, data indicate that the P2Y2 induced phosphorylation of ERK1/2 and the induction of c-Fos are due to the operation of CaM, with PKC, PI3K, EGFR and receptor endocytosis mechanisms endorsing the signalling
González et al., Mol Neurobiol 2005 : Ligation of vitronectin receptors with specific antibodies caused an inhibition of P2Y2 receptor induced ERK1/2 and p38 phosphorylation and P2Y2 receptor induced cytoskeleton rearrangement and DNA synthesis
Boucher et al., Exp Eye Res 2007 : These studies indicate that injury induced purinergic receptor activation leads to phosphorylation of EGFR, ERK and migration
Taboubi et al., FASEB J 2007 : In addition, activation of P2Y2R prevents growth factor induced phosphorylation of Erk ( 1,2 ) and Akt/PkB
Ding et al., J Biol Chem 2011 (MAP Kinase Signaling System) : In addition, P2Y(2) receptor activated ERK1/2 , JNK, and p38 MAPK pathways without affecting the positive NF-?B and negative AKT regulatory pathways of TF expression