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JUN — KLF6
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
JUN
→
Complex of JUN-KLF6
(decreases, JUN/KLF6 Activity)
Slavin et al., Oncogene 2004*
Evidence: here, we demonstrate that KLF6 behaves as a functional antagonist of the c-Jun proto-oncoprotein. Thus, KLF6 overexpression downregulated c-Jun-dependent transcription and a physical interaction between c-Jun and KLF6 was detected
Text-mined interactions from Literome
Slavin et al., Oncogene 2004
:
The inhibition of c-Jun functions correlates directly with
c-Jun protein degradation
induced by
KLF6 ... We also show that all
KLF6 effects on
c-Jun were largely dependent on phorbol ester ( TPA/ionomycin ) extracellular stimulation, which enhanced KLF6 nuclear translocation and transcriptional activity and modified its phosphorylation status
Das et al., Proc Natl Acad Sci U S A 2006
(Atherosclerosis...) :
Mechanistically,
KLF2 inhibits the transcriptional activity of both NF-kappaB and
activator protein 1 , in part by means of recruitment of transcriptional coactivator p300/CBP associated factor