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IRF6 — PGF

Text-mined interactions from Literome

Sautebin et al., Inflamm Res 1999 : AA induced a significant production of 6-ketoPGF1alpha and PGE2, whereas LPS caused a concentration- and time dependent increase of 8-epi-PGF2alpha , 6-keto-PGF1alpha and PGE2 ... DXM ( 2 microM ) as well as CXM ( 1 microM ) significantly decreased ( p < 0.001 ; n = 4 ) the LPS stimulated production of 8-epi-PGF2alpha ( by 86 % and 82 %, respectively ), 6-ketoPGF1alpha ( by 78 % and 74 %, respectively ) and PGE2 ( by 83 % and 78 %, respectively )
Soler et al., J Infect Dis 2001 (Endotoxemia) : Infusion of cPTIO significantly reduced LPS induced mean arterial blood pressure decline and mortality and selectively reduced LPS induced 6-oxo-PGF ( 1alpha ) plasma levels and prostacyclin synthase ( PGIS ) activity measured in the lung and aorta
Kim et al., Phytother Res 2000 (Inflammation...) : In addition, fractions A, D and E had the ability to inhibit the production of LPS induced 6-keto-PGF1alpha production in macrophage cultures
Chen et al., Am J Physiol Lung Cell Mol Physiol 2001 : SNAP, SNP, and NONOate significantly suppressed LPS stimulated COX activity and 6-keto-PGF ( 1alpha ) release
Leung et al., J Endocrinol 2001 : Pro-inflammatory interleukins suppress OTR expression in the late luteal phase, while LPS stimulates PGF ( 2alpha ) without altering OTR mRNA expression ... IL-I and -2 and LPS are therefore unlikely to initiate luteolysis but may cause raised production of PGF ( 2alpha ) during uterine infection
Giuliano et al., J Pharmacol Exp Ther 2001 : Diclofenac ( 3 mg kg ( -1 ), i.p. ) or the COX-2 selective agent diisopropyl fluorophosphate ( 10 mg kg ( -1 ), i.p. ) decreased the LPS induced increase in circulating 6-keto-PGF ( 1alpha ) and the exaggerated 6-keto-PGF ( 1alpha ) production following AA challenge ... ( administered either 1 h prior, or once per day for 3 days prior, to LPS injection ) reduced only the LPS induced increase in circulating 6-keto-PGF ( 1alpha ), but not the exaggerated 6-keto-PGF ( 1alpha ) production following AA challenge or the expression of COX-2
Lappas et al., J Clin Endocrinol Metab 2004 : Treatment of placenta, amnion, and choriodecidua with SASP concentrations greater than 5 mM significantly inhibited basal and/or LPS stimulated type II PLA(2) content and release, 13,14-dihydro-15-keto PGF ( 2alpha ) release, and cPLA(2) protein content ( ANOVA, P < 0.05 ) ; however, no effect of SASP was observed on basal or LPS stimulated COX-1 or COX-2 protein ... Although no effect of SASP was observed on basal and LPS stimulated PGF ( 2alpha ) release from placenta and amnion, it significantly increased both basal and LPS stimulated PGF ( 2alpha ) release from choriodecidua
Herath et al., Endocrinology 2006 : In addition, estradiol and progesterone inhibited the production of PGE and PGF in response to LPS , indicating a role for steroid hormones in the response to bacterial infection
Lappas et al., Placenta 2006 (Inflammation) : Both 15d-PGJ ( 2 ) and troglitazone significantly decreased basal and LPS stimulated PGE ( 2 ) and PGF ( 2alpha ) release from placenta and amnion ... However, in choriodecidua, although 15d-PGJ ( 2 ) decreased basal and/or LPS stimulated PGE ( 2 ) and PGF ( 2alpha ) release, there was an increase in PGE ( 2 ) and PGF ( 2alpha ) release in the presence of troglitazone
Birnbaum et al., Prostaglandins Other Lipid Mediat 2007 : LPS increased 15-epi-LXA4 and 6-keto-PGF ( 1alpha ) levels
Cort et al., Acta Vet Scand 1990 (Abortion, Veterinary...) : In the FM-treated gilts, the LPS induced PGF2 alpha metabolite response was rudimentary and the progesterone decrease temporary in nonaborting gilts
Lappas et al., Biol Reprod 2011 : The SIRT1 activators resveratrol and SRT1720 significantly decreased LPS induced TNF, IL6, and IL8 gene expression and release and PTGS2 mRNA expression and resultant prostaglandin ( PG ) E ( 2 ) and PGF ( 2a ) release from human gestational tissues
Buenestado et al., Br J Pharmacol 2012 : LPS also increased PGE ( 2 ) and 6-keto PGF ( 1a ) release from lung macrophages which was associated with an up-regulation of COX-2 mRNA
Kubatiev et al., Int J Tissue React 1990 : Emoxypin abolished totally LPS induced TxB2 and PGF2 alpha production
Kreil et al., Circ Res 1989 : LPS ( 1 micrograms/kg, n = 11 ) induced a briefer increase of lymph 6-k-PGF1 alpha levels than did rhTNF alpha while plasma 6-k-PGF1 alpha levels did not increase
Durant et al., Int J Tissue React 1985 : In contrast, LPS and RU 41740 ( 5 micrograms/ml ) induced a significant stimulation of PGE2 and 6-keto-PGF1 alpha secretion in the two types of cells
Zingarelli et al., Shock 1995 : In macrophages from tolerant rats LPS stimulated 6-keto-PGF1 alpha production was significantly reduced, while nitrite production was increased compared to control macrophages ( p < .001 )
Gu et al., Prostaglandins Leukot Essent Fatty Acids 1994 : Both LPS and calcium ionophore A23187 stimulated PGF2 alpha release ( p < 0.05 ) ... The data suggest LPS could increase basal PGF2 alpha release from human placenta, combined with A23187 it may act on PG synthase as well in favour of PGF2 alpha formation
Zingarelli et al., Br J Pharmacol 1997 : Similar inhibition of LPS stimulated 6-keto PGF1 alpha production was shown by other mercaptoalkylguanidines ( such as N-methyl-mercaptoethylguanidine, N, N'-dimethyl-mercaptoethylguanidine, S-methyl-mercaptoethylguanidine and guanidino-ethyldisulphide ), with IC50 values ranging between 34-55 microM
Longo et al., Mediators Inflamm 1998 : IL-1beta and LPS increased both PGE2 and 6-keto-PGF1alpha in a dose dependent fashion with enhanced production detected two hours following exposure