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IL6 — LRPPRC

Pathways - manually collected, often from reviews:

• BioCarta il 6 signaling pathway: IL-6 (IL6) → IL-6R-alpha/IL-6R-alpha/GP130/GP130 complex (IL6R-LRPPRC) (modification, collaborate)
  
• BioCarta il 6 signaling pathway: IL-6 (IL6) → IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130 complex (IL6-IL6R-LRPPRC) (modification, collaborate)
  
• BioCarta il 6 signaling pathway: IL-6R-alpha/IL-6R-alpha/GP130/GP130 complex (IL6R-LRPPRC) → IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130 complex (IL6-IL6R-LRPPRC) (modification, collaborate)
  
• BioCarta role of erbb2 in signal transduction and oncology: ERBB2 → IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/ERBB2 complex (IL6-IL6R-LRPPRC-ERBB2) (modification, collaborate)
  
• BioCarta role of erbb2 in signal transduction and oncology: ERBB2 → IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130 complex (IL6-IL6R-LRPPRC) (modification, collaborate)
  
• BioCarta role of erbb2 in signal transduction and oncology: IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/ERBB2 complex (IL6-IL6R-LRPPRC-ERBB2) → IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130 complex (IL6-IL6R-LRPPRC) (modification, collaborate)
  
• BioCarta role of erbb2 in signal transduction and oncology: IL-6 (IL6) → IL-6R-alpha/IL-6R-alpha/GP130/GP130/ERBB2 complex (IL6R-LRPPRC-ERBB2) (modification, collaborate)
  
• BioCarta role of erbb2 in signal transduction and oncology: IL-6 (IL6) → IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/ERBB2 complex (IL6-IL6R-LRPPRC-ERBB2) (modification, collaborate)
  
• BioCarta role of erbb2 in signal transduction and oncology: IL-6R-alpha/IL-6R-alpha/GP130/GP130/ERBB2 complex (IL6R-LRPPRC-ERBB2) → IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/ERBB2 complex (IL6-IL6R-LRPPRC-ERBB2) (modification, collaborate)
  
• BioCarta role of erbb2 in signal transduction and oncology: IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKs complex (IL6-IL6R-LRPPRC-JAK2_JAK1_JAK3) → STAT3 (modification, activates)
• BioCarta il 6 signaling pathway: IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKS complex (JAK2_JAK1_JAK3-LRPPRC-IL6R-IL6) → STAT3 (modification, activates)
• BioCarta il 6 signaling pathway: IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKS complex (JAK2_JAK1_JAK3-LRPPRC-IL6R-IL6) → JAKs (JAK2/JAK1/JAK3) (modification, collaborate)
• BioCarta il 6 signaling pathway: IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKS complex (JAK2_JAK1_JAK3-LRPPRC-IL6R-IL6) → IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130 complex (IL6-IL6R-LRPPRC) (modification, collaborate)
  
• BioCarta il 6 signaling pathway: JAKs (JAK2/JAK1/JAK3) → IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130 complex (IL6-IL6R-LRPPRC) (modification, collaborate)
  
• BioCarta role of erbb2 in signal transduction and oncology: JAKs (JAK2/JAK1/JAK3) → IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130 complex (IL6-IL6R-LRPPRC) (modification, collaborate)
  
• BioCarta role of erbb2 in signal transduction and oncology: JAKs (JAK2/JAK1/JAK3) → IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKs complex (IL6-IL6R-LRPPRC-JAK2_JAK1_JAK3) (modification, collaborate)
  
• BioCarta role of erbb2 in signal transduction and oncology: IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130 complex (IL6-IL6R-LRPPRC) → IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKs complex (IL6-IL6R-LRPPRC-JAK2_JAK1_JAK3) (modification, collaborate)
  
• BioCarta il 6 signaling pathway: IL-6/IL-6/IL-6R-alpha/IL-6R-alpha/GP130/GP130/JAKS complex (JAK2_JAK1_JAK3-LRPPRC-IL6R-IL6) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  

Text-mined interactions from Literome

Pan et al., Heart Vessels 1998 (Cardiomegaly) : These results suggested that gp130 mediated signaling was involved in the pressure overload induced activation of the JAK/STAT pathway, and that IL-6 and CT-1 might be involved in this activation
Nakahata et al., Rinsho Byori 1999 : Addition of anti-gp130 mAbs and anti-IL-6R mAb to the above cultures dose-dependently inhibited the expansion of progenitors, suggesting that gp130 signalling initiated by the sIL-6R/IL-6 complex is important for significant expansion of human hematopoietic stem/progenitor cells
Tanuma et al., J Biol Chem 2000 (Leukemia, Myeloid, Acute) : PTPepsilonC expression resulted in lower levels of IL-6 induced tyrosine phosphorylation of Jak1, Tyk2, gp130 , and Stat3 compared with parent cells
Yokomuro et al., Hepatology 2000 (Bile Duct Neoplasms...) : In both the CCs and BECs, exogenous HGF or IL-6 induced phosphorylation of met or gp130 , respectively, and a concentration dependent increase in DNA synthesis
Tanaka et al., J Clin Invest 2000 (Arthritis, Rheumatoid) : In vitro experiments revealed that gp130-RAPS inhibited IL-6 activity, and this inhibition was neutralized by antibodies to the COOH-terminus of gp130-RAPS derived from patients with RA
Van Bockstaele et al., Ann Hematol 2000 : GP130 and c-kit signalling, initiated by the sIL-6R/IL-6 complex, is insufficient to expand the primitive adult bone marrow CD34+CD38- pre-CFU cell
Erices et al., Exp Cell Res 2002 : Gp130 activation by soluble interleukin-6 receptor/interleukin-6 enhances osteoblastic differentiation of human bone marrow derived mesenchymal stem cells
Snyers et al., Biochem Biophys Res Commun 1992 (Carcinoma, Hepatocellular...) : Enhancement of IL-6 receptor beta chain ( gp130 ) expression by IL-6 , IL-1 and TNF in human epithelial cells
Franchimont et al., Arthritis Rheum 2005 : Interleukin-6 (IL-6) and soluble IL-6 receptor ( sIL-6R ) activation of gp130 represents an alternative pathway for osteoclast development in inflammatory conditions
Giese et al., J Cell Sci 2005 : Taken together, these findings suggest that transient gp130 homodimers on the plasma membrane are stabilized by IL-6 whereas heterodimerization of gp130 with the LIFR is mainly triggered by the ligand
Duan et al., J Biol Chem 2006 : We determined the role of IL-6-receptor-gp130-Stat3 signaling in IL-6 activation of the gammaFBG promoter in liver and lung epithelial cells
Murakami et al., Proc Natl Acad Sci U S A 1991 : Loss of signal transducing ability of gp130 with such a mutation coincided with disappearance of IL-6 induced tyrosine phosphorylation of gp130
Han et al., J Biol Chem 2006 : COX-2 derived PGE ( 2 ) induces interleukin-6 production through activation of EP ( 4 ) receptor and subsequent phosphorylation of gp130/Stat3 in human cholangiocarcinoma cells
Kovacs et al., TheScientificWorldJournal 2006 (Lymphoma, B-Cell...) : In this study, we investigated the effects of IL-6, IL-6 receptor antagonist (IL-6RA), and gp130 antagonist (gp130A) on the membrane expressions of IL-6R and gp130, on the viability, on the proliferation, on the DNA synthesis, and on the cell cycle phases in several multiple myeloma ( MM ) cell lines and B cell lymphoma cell lines
Squarize et al., Neoplasia (New York, N.Y.) 2006 (Carcinoma, Squamous Cell...) : Indeed, the autocrine activation of the gp130 cytokine receptor in HNSCC cells by tumor released cytokines, such as IL-6 , can result in the EGFR independent activation of STAT3
Yeoh et al., Hepatology 2007 : Gp130 mediated IL-6 signaling may play a role in oval cell proliferation in vivo
Wang et al., Circ Res 2007 (Carotid Artery Injuries...) : In addition, IL-6 stimulated tyrosine phosphorylation of gp130 , resulting in the recruitment and activation of STAT-3
Canellada et al., J Steroid Biochem Mol Biol 2008 : We found that the IL-6 treatment induced an increase in the expression of gp130 and JAK1 by the hybridoma ... E2 and P4 diminished the IL-6 induced gp130 expression in a dose dependent manner, whereas the expression of JAK1 was not significantly affected
Suh et al., J Cell Physiol 2009 : IL-6 ( 10 ng/ml ) increased the level of IL-6Ralpha and glycoprotein (gp) 130 ( IL-6Rbeta ) protein expressions
Mees et al., J Surg Res 2009 (Disease Models, Animal...) : Binding of the IL-6/sIL-6R complex by gp130-Fc led to significant lower IL-6 levels compared with placebo treated animals
Shariat et al., J Urol 2011 (Disease Progression...) : Soluble gp130 regulates prostate cancer invasion and progression in an interleukin-6 dependent and independent manner ... Data suggest that soluble gp130 has a role in prostate cancer invasion in an interleukin-6 dependent and independent manner
Kishimoto et al., Stem Cells 1994 : Interaction of IL-6 and IL-6 receptor induces homodimerization of gp130 which interacts and activates an intracytoplasmic tyrosine kinase, JAK-1 kinase
Murakami et al., Science 1993 : Binding of IL-6 to IL-6R induced disulfide linked homodimerization of gp130
Peppard et al., J Biol Chem 1996 (Carcinoma, Hepatocellular...) : When the binding of IL-6 to its receptor complex was dissected in vitro, inhibition of binding of IL-6 to soluble receptor by the extract was not detected, but binding of the IL-6-sIL-6R complex to soluble gp130 was inhibited in a dose dependent fashion
Ehlers et al., J Interferon Cytokine Res 1996 : The construction of chimeric human/murine IL-6 proteins has allowed us to define a region ( residues 77-95, region 2c ) within the human IL-6 protein that is important for IL-6R binding and a region ( residues 50-55, region 2a2 ) that is important for IL-6R dependent gp130 interaction
Berger et al., Blood 1997 (Multiple Myeloma) : Further analysis indicated that treatment with IFN-beta disrupted IL-6 induced binding of PTP1D/Syp to gp130 and the adaptor protein Grb2 ; IFN-beta pretreatment also interfered with IL-6 induced interaction of Shc with Grb2 and a 145-kD tyrosine phosphorylated protein
Giordano et al., J Immunol 1997 : IL-6 induces homodimerization of gp130 and activates the Jak/STAT pathway of signal transduction
Kalai et al., Eur J Biochem 1997 : Our results show that several anti-human IL-6 and anti-human IL-6R neutralising mAbs block the binding between human IL-6 and human IL-6R, whereas others block the binding to gp130
März et al., Eur J Neurosci 1997 : Activation of gp130 by IL-6/soluble IL-6 receptor induces neuronal differentiation
Dahmen et al., Biochem J 1998 : Activation of the signal transducer gp130 by interleukin-11 and interleukin-6 is mediated by similar molecular interactions
Ogata et al., Clin Cancer Res 1997 (Multiple Myeloma) : gp130 phosphorylation, gp130-to-PTP1D binding, PTP1D phosphorylation, and PTP1D-to-Grb2 binding are also induced by IL-6 in all IL-6 independent MM cell lines studied