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GNLY — IL2

Text-mined interactions from Literome

Zheng et al., Blood 2007 (HIV Infections) : Cryptococcal killing by CD4+ T cells was defective in human immunodeficiency virus ( HIV ) -infected patients due to dysregulated granulysin and perforin production in response to IL-2 or anti-CD3 + IL-2
Latinovic-Golic et al., BMC immunology 2007 : This first comprehensive study of granulysin gene regulation in primary cultured human lymphocytes shows that the regulation of granulysin synthesis in response to IL-2 or bacterial antigen stimulation occurs at several levels : RNA expression, extensive alternative splicing and posttranslational processing
Zheng et al., J Immunol 2008 (HIV Infections) : This is because CD4 ( + ) T cells from HIV infected patients fail to produce granulysin in response to IL-2 activation ... We demonstrate that IL-2 initially requires both STAT5 and PI3K activation to increase expression of IL-2Rbeta, produce granulysin , and kill C. neoformans ... The increased expression of IL-2Rbeta precedes granulysin, and preventing the increased expression of IL-2Rbeta using small interfering RNA knockdown abrogates granulysin expression