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CDC73 — PRKCA

Text-mined interactions from Literome

Calcerrada et al., Prostaglandins Other Lipid Mediat 2005 : PAF induced an increase of PKC alpha activity, whereas a decrease rather than increase in PKC zeta was observed by using immunoprecipitation assays
Faghiri et al., Invest Ophthalmol Vis Sci 2006 : Pretreatment with PKC inhibitor calphostin C abolished the PAF induced translocation of PKCalpha to the plasma membrane or to the Golgi, but the Golgi inhibitor Brefeldin A only prevented the accumulation of PKCalpha in Golgi, without affecting its membrane relocalization ... PAF promoted depletion of PKCalpha and delta isoforms but not that of PKCbeta ... Proteasome inhibitors lactacystin and MG-132 prevented the PAF induced depletion of PKCalpha , but the inhibitor of lysosomal proteolysis E-64d was ineffective in rescuing PKCalpha ... These results suggest that the PAF induced downregulation of PKCalpha occurs principally through the proteasomal pathway