Gene interactions and pathways from curated databases and text-mining

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CDKN1A — PSEN1

Text-mined interactions from Literome

Shimoyama et al., Arterioscler Thromb Vasc Biol 2010 (Diabetes Mellitus, Experimental...) : Gamma secretase inhibitor, an inhibitor of Notch signaling, partially inhibited the enhanced expression of p21 induced by CCN3
Bialopiotrowicz et al., J Alzheimers Dis 2012 (Alzheimer Disease) : Altogether, we found that both CC regulation and Aß production differentiate PS1 mutations, and that CC PS1 activity is mediated by p53/p21 signaling but not by ?-secretase activity