◀ Back to GRB2
AKT1 — GRB2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Lim et al., Oncogene 2000
(Breast Neoplasms) :
Since Akt can also be activated by heregulin, the
effects of
Grb2 inhibition on
Akt were examined
Tari et al., Oncogene 2002
(Breast Neoplasms) :
Liposome incorporated Grb2 antisense oligonucleotides ( L-Grb2 ) and a dominant negative ( DN ) AKT mutant were used to down-regulate
Grb2 expression and
inhibit Akt activity, respectively
Liu et al., Am J Physiol Endocrinol Metab 2009
(Insulin Resistance) :
Suppressing
Grb2 expression in C ( 2 ) C ( 12 ) myoblasts
enhances insulin stimulated insulin receptor substrate (IRS)-1, tyrosine phosphorylation, and
Akt phosphorylation, which is associated with decreased IRS-1 serine phosphorylation at residues 307, 612, and 636/639
Samoylenko et al., Carcinogenesis 2012
(Adenocarcinoma...) :
Thereby, Ruk ( l )
/CIN85 led to a more rapid and prolonged epidermal growth factor dependent activation of Src,
Akt and ERK1/2 and treatment with the Src inhibitor PP2 and the PI3K inhibitor LY294002 abolished the Ruk ( l ) /CIN85 dependent changes in cell motility