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GSK3B — NOTCH1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: GSK3B — NOTCH1 (direct interaction, enzymatic study) Foltz et al., Curr Biol 2002*
• IRef Biogrid Interaction: GSK3B — NOTCH1 (direct interaction, pull down) Foltz et al., Curr Biol 2002*
• IRef Ophid Interaction: GSK3B — NOTCH1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: GSK3B — NOTCH1 (aggregation, confirmational text mining) Foltz et al., Curr Biol 2002*

Text-mined interactions from Literome

Espinosa et al., J Biol Chem 2003 : Consistent with this, GSK-3 beta inhibits the transcriptional activation of Notch target genes both in vitro and in vivo, whereas lithium chloride treatment or Wnt-1 overexpression that results in GSK-3 beta inhibition leads to the up-regulation of the Hes-1 promoter ... Together, our results suggest that cross-talk between Notch and Wnt pathways may be partially mediated by specific regulation of GSK-3 beta dependent Notch phosphorylation
Lee et al., Cancer Lett 2008 : Taken together, the results of this study indicate that indirubin-3'-monoxime downregulated Notch1 signaling in a GSK-3beta dependent and proteosomal degradation independent manner
Adler et al., Ann Surg Oncol 2009 (Carcinoid Tumor...) : Treatment of carcinoid cells with either VPA or SBHA and lithium chloride suppresses the neuroendocrine marker CgA while upregulating Notch1 and inhibiting GSK-3beta
Guha et al., Basic Res Cardiol 2011 (Neointima) : Glycogen synthase kinase 3 beta positively regulates Notch signaling in vascular smooth muscle cells : role in cell proliferation and survival