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CDKN1A — FAS

Text-mined interactions from Literome

Menendez et al., Int J Oncol 2004 (Breast Neoplasms) : In SK-Br3 cells, cerulenin induced inhibition of FAS activity resulted in down-regulation of p53, and up-regulation of cyclin dependent kinase inhibitor (CDKi) p21WAF1/CIP1
Menendez et al., Oncogene 2004 (Adenocarcinoma...) : Moreover, depletion of FAS by RNAi also caused loss of ERalpha expression, downregulation of PR, and accumulation of p21WAF1/CIP1 and p27Kip1 in E2-stimulated Ishikawa cells
Zhang et al., J Biol Chem 2008 : Overexpression of p21 suppressed MDM2, elevated p53 levels, and enhanced CD95 , BAX, NOXA, and PUMA expression ; knockdown of BAX/NOXA/PUMA reduced CDK inhibitor stimulated cell killing
Sharma et al., Am J Obstet Gynecol 2009 (Ovarian Neoplasms) : OM-3FAs increased the level of TGF-beta1, Smad-3, and p21 protein in ovarian cancer cells known to be more sensitive to their inhibitory effect