Gene interactions and pathways from curated databases and text-mining

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PARP1 — SELP

Text-mined interactions from Literome

Hassa et al., J Biol Chem 2001 : Finally, we showed that PARP-1 is activating the natural inducible nitric-oxide synthase and P-selectin promoter in a kappa B-dependent manner upon stimulation of the cells with inflammatory stimuli or cotransfection of p65
Cuzzocrea et al., Biochem Pharmacol 2002 (Disease Models, Animal...) : The potent PARP inhibitor 5-aminoisoquinolinone ( 5-AIQ ) reduced the degree of lung injury and attenuated the expression of P-selectin and ICAM-1 as well as the recruitment of neutrophils into the injured lung
Cuzzocrea et al., Shock 2004 (Reperfusion Injury...) : Administration of WY 14643 also markedly reduced the nitrotyrosine formation, poly ( adenosine diphosphate [ ADP ] -ribose ) polymerase ( PARP ) activation , up-regulation of ICAM-1, and expression of P-selectin during reperfusion