◀ Back to PLAU
PLAU — TP53
Text-mined interactions from Literome
Shetty et al., J Biol Chem 2005
(Inflammation) :
Single chain
uPA also
enhanced p53 expression to the same extent as intact two chain active uPA and the amino-terminal fragment ... Pretreatment of cells with anti-beta1 integrin antibody blocked
uPA induced
p53 expression ...
uPA induced
p53 expression occurs without increased p53 mRNA expression ...
uPA induced
p53 expression does not require activation of tyrosine kinases ... Inactivation of protein-tyrosine phosphatase SHP-2 inhibits both basal and
uPA induced
p53 expression ... Plasmin did not alter
uPA mediated
p53 expression
Shetty et al., Mol Cell Biol 2007
(Lung Neoplasms) :
Inhibition of
p53 by RNA silencing in Beas2B human airway epithelial cells conversely
increased basal as well as
uPA mediated uPAR expression and stabilized uPAR mRNA
Shetty et al., Am J Physiol Lung Cell Mol Physiol 2008
(Acute Lung Injury...) :
In addition,
uPA mediated signaling
controls the expression of the tumor suppressor protein
p53 in lung epithelial cells at the posttranslational level
Bhandary et al., Am J Physiol Lung Cell Mol Physiol 2012
(Acute Lung Injury...) :
Thus
p53 is increased and
inhibits expression of
uPA and uPAR while increasing PAI-1, changes that promote ATII cell apoptosis in mice with BLM induced ALI ... We show that CSP, an intervention targeting this pathway, protects the lung epithelium from apoptosis and prevents PF in BLM induced lung injury via
uPA mediated inhibition of
p53 and PAI-1