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LEP — POMC

Text-mined interactions from Literome

Korner et al., Neuroendocrinology 1999 (Obesity) : Regulation of hypothalamic proopiomelanocortin by leptin in lean and obese rats ... Furthermore, the acute increase in the levels of POMC primary transcript in non-obese rats after a single i.c.v. injection of leptin supports a role for leptin in the regulation of POMC gene transcription
Morimoto et al., Neuroendocrinology 2000 : The leptin induced CRH mRNA expression in the PVN and POMC mRNA expression in the pituitary were also reduced by the pretreatment with OPC-21268 and dP [ Tyr ( Me)(2 ) ] AVP
Mori et al., Nihon rinsho. Japanese journal of clinical medicine 2001 : POMC gene expression in hypothalamus is partially regulated by leptin
Fukagawa et al., Nihon rinsho. Japanese journal of clinical medicine 2001 (Disease Models, Animal...) : Leptin is an anorectic ob gene product and activates the anorexigenic POMC and CART neurons in the ARC and suppresses orexigenic NPY and AGRP neurons
Swart et al., Am J Physiol Regul Integr Comp Physiol 2002 (Body Weight) : Hypothalamic NPY, AGRP, and POMC mRNA responses to leptin and refeeding in mice
Vrang et al., J Neuroendocrinol 2002 (Body Weight) : Effects of leptin on arcuate pro-opiomelanocortin and cocaine-amphetamine regulated transcript expression are independent of circulating levels of corticosterone ... Similarly, leptin caused an identical increase in arcuate POMC and CART mRNA expression in ob/ob-sham and ob/ob-ADX compared to vehicle
Proulx et al., Endocrinology 2002 (Weight Gain) : In the arcuate nucleus (ARC), acute leptin increased SOCS-3 and POMC mRNA levels, but decreased NPY mRNA levels in the rostral part of ARC ... We conclude that despite adult-like effects of leptin on POMC , NPY, and CRFR-2 expression in neonates, leptin does not regulate food intake during early development
Münzberg et al., Endocrinology 2003 : Role of signal transducer and activator of transcription 3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin ... These cells express the leptin receptor ObRb, and leptin can regulate POMC mRNA levels, but the cellular mechanisms by which this occurs is unknown ... In pomc-promoter assays using transfected cells, leptin induces pomc promoter activity
Wilsey et al., Am J Physiol Regul Integr Comp Physiol 2003 (Body Weight...) : rAAV-leptin caused an increase in STAT3 phosphorylation and proopiomelanocortin expression in the hypothalamus and an increase in uncoupling protein-1 in brown adipose tissue in both Chow and DR animals, but failed to do so in DIO
Bjørbaek et al., Recent Prog Horm Res 2004 : Regulation of the pro-opiomelanocortin (pomc) and the thyrotropin releasing hormone (trh) genes by leptin is particularly well understood
Pinto et al., Science 2004 (Body Weight) : The fat derived hormone leptin regulates energy balance in part by modulating the activity of neuropeptide Y and proopiomelanocortin neurons in the hypothalamic arcuate nucleus
Mori et al., Nat Med 2004 (Insulin Resistance...) : Compared to their wild-type littermates, Socs3-deficient mice showed enhanced leptin induced hypothalamic Stat3 tyrosine phosphorylation as well as pro-opiomelanocortin (POMC) induction, and this resulted in a greater body weight loss and suppression of food intake
Breen et al., Brain Res 2005 : Agouti related protein (AGRP) and proopiomelanocortin (POMC) have opposing effects on melanocortin receptor ( MC-R ) signaling and energy balance, and are important targets for leptin and insulin in the hypothalamus
Horvath et al., Obesity (Silver Spring) 2006 : Leptin regulates energy balance, in part, by modulating the activity of neuropeptide Y (NPY) and proopiomelanocortin (POMC) neurons in the hypothalamic arcuate nucleus
Carlo et al., Endocrinology 2007 : However, leptin down-regulated mRNA levels of proopiomelanocortin and neuropeptide Y and decreased somatostatin secretion
van de Wall et al., Endocrinology 2008 (Hyperinsulinism...) : Thus, AgRP/NPY and POMC neurons each play mandatory roles in aspects of leptin regulated energy homeostasis, high leptin levels in adult mice mitigate the importance of leptin-responsiveness in these neurons for components of energy balance, suggesting the presence of other leptin regulated pathways that partially compensate for the lack of leptin action on the POMC and AgRP/NPY neurons
Hirosawa et al., Biochem Biophys Res Commun 2008 (Diabetes Mellitus...) : Ablation of estrogen receptor alpha (ERalpha) prevents upregulation of POMC by leptin and insulin
Yang et al., J Biol Chem 2009 : FoxO1 inhibits leptin regulation of pro-opiomelanocortin promoter activity by blocking STAT3 interaction with specificity protein 1 ... We show that phospho-STAT3 activates POMC promoter in response to leptin signaling through a mechanism that requires an SP1 binding site in the POMC promoter
Lectez et al., Endocrinology 2009 : Finally, 26RFa antagonized the effects of leptin on NPY expression and release, POMC expression and alpha-MSH release, and food intake
Hill et al., Endocrinology 2009 (Obesity) : This regulation involves proopiomelanocortin (POMC) neurons because suppression of phosphatidyl inositol 3-kinase (PI3K) signaling in these neurons blunts the acute effects of insulin and leptin on POMC neuronal activity
Jang et al., J Biol Chem 2010 (Anorexia) : In addition, hypothalamic NF-kappaB was activated by leptin , an important anorexigenic hormone, and mediates leptin stimulated POMC transcription, indicating that hypothalamic NF-kappaB also serves as a downstream signaling pathway of leptin
Williams et al., J Neurosci 2010 : Interestingly, both insulin and leptin regulate POMC cellular activity by activation of PI3K ; however, it is unclear whether leptin and insulin effects are observed in similar or distinct populations of POMC cells
Ghamari-Langroudi et al., Proc Natl Acad Sci U S A 2011 : Thus, in contrast with the conventional model of leptin action, the primary control of MC4R PVN neurons is unlikely to be mediated by leptin action on arcuate NPY/agouti related protein and proopiomelanocortin neurons
Pankov et al., Biomedit͡sinskai͡a khimii͡a 2010 (Obesity) : Expression of POMC that codes MSH is enhanced by leptin binding to the receptor ( LepRb ) in hypothalamic neurons
Sahu et al., Neurosci Lett 2011 : Recently, we have demonstrated that cilostamide reversed the leptin induced increase in proopiomelanocortin (POMC) gene expression in the hypothalamus
Xu et al., Endocrinology 2012 (Body Weight...) : Previous results demonstrate that leptin mainly acts on ?-aminobutyric acid ( GABA ) ergic neurons to reduce body weight, and that leptin activates proopiomelanocortin neuron activity by reducing GABA release onto these neurons, suggesting a body weight promoting role for GABA released from leptin inhibited neurons
Schwartz et al., Diabetes 1997 : Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus