◀ Back to PARP1

PARP1 — PARP16

Text-mined interactions from Literome

Besson et al., Free radical research 2003 (Brain Diseases) : The PARP inhibitor, 3-aminobenzamide, significantly reduced the lesion and inhibited PARP-1 activation induced by malonate
Xiao et al., J Pharmacol Exp Ther 2005 (Aortic Diseases...) : The catalytic activity of PARP was inhibited by the potent isoindolinone based PARP inhibitor INO-1001 or by PARP-1 genetic deficiency
Tapodi et al., J Biol Chem 2005 (Necrosis) : To clarify the molecular mechanism of cytoprotection, PARP activity was inhibited pharmacologically by suppressing PARP-1 expression by a small interfering RNA ( siRNA ) technique or by transdominantly expressing the N-terminal DNA binding domain of PARP-1 ( PARP-DBD ) in cultured cells
Kedar et al., DNA repair 2008 : Interaction between PARP-1 and ATR in mouse fibroblasts is blocked by PARP inhibition
Choi et al., Hypertension 2012 (Body Weight...) : Interestingly, PARP-1 inhibitors significantly reduced the potentiation of myogenic tone, improved endothelium dependent relaxation, restored endothelial NO synthase phosphorylation and cGMP, and attenuated cleaved PARP-1
Schiewer et al., Cancer Discov 2012 (Disease Progression...) : It was further confirmed in genetically defined systems that PARP-1 supports AR transcriptional function, and that in models of advanced prostate cancer, PARP-1 enzymatic activity is enhanced , further linking PARP-1 to AR activity and disease progression
King et al., J Biol Chem 2012 : PARP activation following UVR exposure promotes association between PARP-1 and XPA, a central protein in NER
Tentori et al., Int J Oncol 2013 : Remarkably, inhibition of PARP function by PARPi or by PARP-1 gene silencing always increased the antitumor activity of irinotecan, even in the presence of low PARP-1 expression
Jog et al., Cell death & disease 2013 : Although PARP-1 was activated in both male and female mice, PARP-1 inhibition reduced necrosis only in the male mice