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CTGF — EPHB2

Text-mined interactions from Literome

Yosimichi et al., Eur J Biochem 2001 : In the proliferation phase, CTGF/Hcs24 induced a approximately fivefold increase in the phosphorylation of p44/42 MAPK/ERK and a approximately twofold increase in that of p38 MAPK in an in vivo kinase assay
Chen et al., Kidney Int 2002 (MAP Kinase Signaling System) : Ras/MEK/ERK , protein kinase C ( PKC ) and tyrosine kinase activity also contribute to basal and TGF-beta induced CTGF promoter activity in cultured mesangial cells
Leask et al., J Biol Chem 2003 : Now we show that protein kinase C and Ras/MEK/ERK are necessary for the TGF-beta induction of the CTGF promoter but not of a generic Smad-responsive promoter ( SBE-lux )
Phanish et al., Nephron. Experimental nephrology 2005 (Fibrosis...) : TGF-beta1 induced connective tissue growth factor ( CCN2 ) expression in human renal proximal tubule epithelial cells requires Ras/MEK/ERK and Smad signalling
Liu et al., J Cell Biochem 2006 : Inhibitors of ERK1/2 and JNK but not p38MAPK inhibited the BK- and AngII stimulated expression of CTGF in cells expressing either the WT or mutant receptors, illustrating that ERK and JNK participate in the control of CTGF expression in a manner that appears to be independent of G-protein
Black et al., J Biol Chem 2007 (Fibrosis...) : In lung fibroblasts, inhibition of the TGFbeta1 stimulated CCN2/CTGF by PGE ( 2 ), butaprost, or forskolin is due to p38, ERK , and JNK MAP kinase inhibition that is cAMP dependent
Wickert et al., Comparative hepatology 2007 : Inhibition of Erk downstream activation decreased TGF-beta induced CTGF and PAI-1 expression to a basal level ... The data provide evidence that beside the TGF-beta-Smad 3 pathway CTGF and PAI-1 expression is additionally dependent on Erk activity in hepatocytes giving new insights into regulation of the profibrogenic proteins
Chen et al., J Cell Sci 2007 (Breast Neoplasms...) : A neutralizing antibody against integrin alphavbeta3 significantly attenuated CTGF mediated ERK1/2 activation and cellular migration, indicating that the integrin-alphavbeta3-ERK1/2 signaling pathway is crucial in mediating CTGF function
Kwon et al., Int J Oncol 2007 (MAP Kinase Signaling System...) : Whereas p38 mediated CTGF induction by TGFbeta in fibroblasts, MEK/ERK signaling mediated TGFbeta induced CTGF expression in pancreatic cancer cells and was also responsible for basal CTGF expression in pancreatic cancer cell lines with defective Smad signaling
Chen et al., Br J Pharmacol 2008 : Curcumin inhibits connective tissue growth factor gene expression in activated hepatic stellate cells in vitro by blocking NF-kappaB and ERK signalling
Arnott et al., Bone 2008 : Using dominant negative ( DN ) mutants for Erk, Jnk and p38, we demonstrated that the expression of DN-Erk caused a significant inhibition of TGF-beta1 induced CTGF promoter activity
Nagai et al., Invest Ophthalmol Vis Sci 2009 : CTGF increased the phosphorylation of p38 and ERK1/2
Lee et al., J Korean Med Sci 2009 (Anoxia...) : Either JNK or ERK inhibitor did not block the hypoxia induced stimulation of CTGF , whereas an inhibitor of p38 MAPK reduced the hypoxia induced changes of CTGF
Droppelmann et al., J Biol Chem 2009 : Additionally, in MMP-2-deficient cells CTGF did not induce the formation of stress fibers, focal adhesion sites, and ERK phosphorylation
Nakamura et al., Exp Mol Med 2009 (MAP Kinase Signaling System) : Calcitonin induces connective tissue growth factor through ERK1/2 signaling in renal tubular cells ... Our present findings suggest that CT induces the transcription of CTGF through ERK1/2 phosphorylation
Wang et al., Cancer Res 2009 (Breast Neoplasms) : A neutralizing antibody against integrin alpha(v)beta ( 3 ) significantly attenuated CTGF mediated ERK1/2 activation and up-regulation of Bcl-xL and cIAP1, indicating that the integrin alpha(v)beta ( 3 ) /ERK1/2 signaling pathway is essential for CTGF functions
Wu et al., Growth Factors 2008 : CTGF enhanced the mRNA expressions and protein release of fractalkine, MCP-1 and RANTES, and the expressions of phosphorylated ERK1/2 , PI3-K and PKB, and activities of NF-KB ... PI3-K blockade downregulated the CTGF stimulated expressions of phosphorylated PI3-K, PKB and NF-kappaB but not phosphorylated ERK1/2 , partially decreased the expressions of the above chemokines
Xiao et al., Cell Physiol Biochem 2011 : These results suggest that stretch induced CTGF expression is mediated through the PI3K-JNK -dependent pathway, not by p38 MAP kinase and ERK pathways
Hu et al., Arch Dermatol Res 2013 (Cicatrix, Hypertrophic...) : The role of ERK and JNK signaling in connective tissue growth factor induced extracellular matrix protein production and scar formation