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BMP2 — MGP
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
BMP2
→
MGP
(decreases)
Zebboudj et al., J Biol Chem 2002*
Evidence: Matrix GLA protein (MGP) has been identified as a calcification inhibitor in cartilage and vasculature. Part of this effect may be attributed to its influence on osteoinductive activity of bone morphogenetic protein-2 (BMP-2).
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Zebboudj et al., J Biol Chem 2002
:
To quantify the
effect of
MGP on
BMP-2 activity, we assayed for alkaline phosphatase activity and showed a dose dependent effect ... To determine the cellular localization of
BMP-2 in the
presence of
MGP , binding assays were performed on whole cells and cell synthesized matrix ... Inhibitory levels of MGP yielded increased matrix binding of BMP-2, suggesting that
MGP inhibits
BMP-2 in part via matrix association
Yao et al., Cardiovasc Res 2007
(Coronary Artery Disease) :
In turn, activated ALK1 induced expression of
matrix GLA protein (MGP) , a
BMP-2 inhibitor known to limit condensation size
Yao et al., J Biol Chem 2007
(Constriction, Pathologic...) :
Deficiency of
matrix GLA protein (MGP) , an
inhibitor of
bone morphogenetic protein (BMP)-2/4 , is known to cause arterial calcification and peripheral pulmonary artery stenosis
Yao et al., Circ Res 2008
(Calcinosis) :
MGP binds calcium ions through gamma carboxylated glutamates ( Gla residues ) and
inhibits bone morphogenetic protein (BMP)-2/-4
Borrás et al., Exp Eye Res 2009
(Calcinosis...) :
Overexpressing
MGP reduces the ALP activity induced by
bone morphogenetic 2 (BMP2) , a potent inducer of calcification
Yao et al., Circ Res 2010
(Atherosclerosis...) :
To investigate the effect of altered expression of
matrix Gla protein (MGP) , an
inhibitor of
BMP , on vascular disease ...
MGP overexpression
reduced vascular
BMP activity, atherosclerotic lesion size, intimal and medial calcification, and inflammation ... Conversely,
MGP deficiency
increased BMP activity, which may explain the diffuse calcification of vascular medial cells in MGP deficient aortas and the increase in expression of activin-like kinase receptor 1 and vascular endothelial growth factor
Yao et al., J Clin Invest 2011
(Arteriovenous Malformations...) :
Mechanistically,
MGP deficiency
increased BMP activity in lungs
Li et al., Arch Oral Biol 2012
:
mRNA expression of
MGP and BMP-2 generally decreased, although MGP mRNA increased on day 14 and 21 compared with the control, and protein expression of MGP and
BMP-2 was
down-regulated