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ADCY9 — IAPP

Text-mined interactions from Literome

D'Santos et al., Mol Pharmacol 1992 : Stimulation of adenylate cyclase by amylin in CHO-K1 cells
Morishita et al., Diabetes Res Clin Pract 1992 : These results suggest that ( 1 ) IAPP-NH2 but not IAPP-COOH induces adenylate cyclase activation via CGRP receptors on rat liver plasma membranes, and ( 2 ) CGRP might not involve its action on the liver in the changes of glucose metabolism
Morishita et al., Diabetes 1990 : Activation of adenylate cyclase by islet amyloid polypeptide with COOH-terminal amide via calcitonin gene related peptide receptors on rat liver plasma membranes
Stroop et al., J Bone Miner Res 1995 (Breast Neoplasms...) : Nevertheless, human amylin and human calcitonin gene related product ( hCGRP ) activate adenylate cyclase with EC50s of 0.7 nM and 8 nM, respectively
Houslay et al., J Cell Biochem 1994 : Regulation of hepatocyte adenylate cyclase by amylin and CGRP : a single receptor displaying apparent negative cooperatively towards CGRP and simple saturation kinetics for amylin, a requirement for phosphodiesterase inhibition to observe elevated hepatocyte cyclic AMP levels and the phosphorylation of Gi-2 ... Both amylin and CGRP similarly activated adenylate cyclase , around 5-fold, although approximately 400-fold higher levels of amylin were required to elicit half maximal activation ... Amylin activated adenylate cyclase though apparently simple Michaelien kinetics whereas CGRP elicited activation by kinetics indicative of apparent negative co-operativity ... Use of the antagonist CGPP ( 8-37 ) showed that both CGRP and amylin activated hepatocyte adenylate cyclase through a common receptor by a mnemonical mechanism where it was proposed that the receptor co-existed in interconvertible high and low affinity states for CGRP
Bushfield et al., Biochem J 1993 : A mnemonical or negative-co-operativity model for the activation of adenylate cyclase by a common G-protein coupled calcitonin-gene related neuropeptide ( CGRP ) /amylin receptor ... Both amylin and calcitonin-gene related neuropeptide ( CGRP ) activated adenylate cyclase activity in hepatocyte membranes around 5-fold in a dose dependent fashion, with EC50 values of 120 +/- 14 and 0.3 +/- 0.14 nM respectively ... Dose-effect data for inhibition of CGRP action by CGRP- ( 8-37 ) showed normal saturation kinetics ( h approximately 1 ), whereas CGRP- ( 8-37 ) inhibited amylin stimulated adenylate cyclase activity in a fashion which was indicative of either multiple sites or apparent negative co-operativity ( h approximately 0.24 ) ... Observed changes in the kinetics of inhibition by CGRP- ( 8-37 ) of CGRP, but not amylin stimulated adenylate cyclase , at concentrations of agonists below their EC50 values militated against a model of two distinct populations of non interacting receptors each able to bind both amylin and CGRP