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ATF4 — TNFSF11
Text-mined interactions from Literome
Yu et al., Ann N Y Acad Sci 2006
(Bone Resorption) :
ATF4 regulates the timely onset of osteoblast differentiation, the synthesis of type I collagen, and the transcription of the osteocalcin and
RANKL ( receptor activator of NFkappa-B ligand ) genes
Cao et al., J Clin Invest 2010
(Bone Diseases, Metabolic...) :
We further showed that
ATF4 was an upstream activator of the critical transcription factor Nfatc1 and was
critical for
RANKL activation of multiple MAPK pathways in OCL progenitors