Mao et al., J Clin Invest 2006
:
Specifically, we show that NFATc1 upregulation is dependent on RANKL mediated phosphorylation of PLCgamma2 downstream of Dap12/Fc receptor gamma ( Dap12/FcRgamma ) receptors and is blocked by the PLCgamma inhibitor U73122
Chen et al., J Biol Chem 2008
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Importantly, PLCgamma2 deficiency severely impaired RANKL signaling, resulting in marked reduction of RANKL induced activation of MAPKs, p38 and JNK, but not ERK