◀ Back to MAPK6
MAPK6 — MMP2
Text-mined interactions from Literome
Ishibashi et al., IUBMB Life 2001
:
The data suggest that interaction between fibroblasts and extracellular matrix components via alpha2 integrin plays an important role in regulating secretion and activation of
72-kDa gelatinase and that down-regulation of activated p42
MAPK may be
involved in the 72-kDa progelatinase activation mechanism
Zhang et al., Biochem Biophys Res Commun 2002
(Carcinoma, Small Cell...) :
These results strongly suggest that
FAK-MAPK signaling is
involved , at least in part, in HA-dependent activation of
MMP-2 secretion in QG90 cells
Zhang et al., Cancer Res 2002
(Carcinoma, Small Cell...) :
In addition, pretreatment of cells with the neutralizing anti-CD44 antibody significantly inhibited both the HA-dependent
MMP-2 secretion and the HA-dependent
activation of
mitogen activated protein kinase in a dose dependent manner
Zhao et al., Radiat Res 2004
(MAP Kinase Signaling System) :
Radiation induced up-regulation of
Mmp2 involves increased mRNA stability, redox modulation, and
MAPK activation
Huang et al., Cancer Res 2005
(Prostatic Neoplasms) :
Inhibition of p38
MAPK by either SB203580 or dominant negative construct
blocked induction of
MMP-2 and cell invasion by TGF-beta ... This study shows that p38
MAPK is
necessary for TGF-beta mediated induction of
MMP-2 and cell invasion in prostate cancer and that genistein blocks activation of p38 MAPK, thereby inhibiting processes closely linked to metastasis, and does so at concentrations associated with dietary consumption
Dai et al., Ann Rheum Dis 2005
(Arthritis...) :
In chondrocytes responding to IL18, IL18 ( 1-100 ng/ml ) slightly increased the production of MMP-1,
MMP-3 , and MMP-13, which was
blocked by NF-kappaB inhibitor and p38
mitogen activated protein kinase inhibitor
Hong et al., Exp Mol Med 2005
(Melanoma...) :
In addition, the down-regulation of p38
MAPK and JNK by siRNA transfection
resulted in a decrease in
MMP-2 expression by MelJuso cells
Melnikova et al., J Biol Chem 2006
(Melanoma...) :
PAF induced
MMP-2 activation was also
down-regulated by p38
MAPK and protein kinase A inhibitors
Song et al., Endocrinology 2007
(Breast Neoplasms) :
In noncancer cells, IGF-I initiates a linear process involving activation of the IGF-I receptor (IGF-IR) and
matrix metalloproteinases ( MMP ) , release of heparin binding epidermal growth factor ( HB-EGF ), and
activation of EGF receptor (EGFR) dependent
MAPK
d'Abusco et al., Arthritis Res Ther 2007
(MAP Kinase Signaling System) :
These findings demonstrate, for the first time, that glucosamine
inhibits IL-1beta stimulated
MMP production in human chondrocytes by affecting
MAPK phosphorylation
Uttamsingh et al., Oncogene 2008
(Cell Transformation, Neoplastic) :
Among them, the expression of MMP1, MMP3,
MMP9 and MMP10 was
MAPK dependent
Ding et al., Osteoarthritis Cartilage 2008
:
To define the
role of
mitogen activated protein ( MAP ) kinases in fibronectin fragment ( Fn-f ) mediated
matrix metalloproteinase ( MMP ) upregulation and damage to bovine cartilage and to compare activities of three Fn-fs with native fibronectin ( Fn ), which is inactive in terms of cartilage damage
Chetty et al., Cancer Res 2008
(Lung Neoplasms...) :
Furthermore,
Ad-MMP-2-Si-CM inhibited AKT phosphorylation and induced phosphorylation of extracellular signal regulated kinase ( ERK )
/mitogen activated protein kinase in endothelial cells
Kumar et al., Cancer Res 2010
(Neoplasm Invasiveness...) :
Conversely, p38
MAPK inhibition
blocked the MAPKAPK2 mediated increase in
MMP-2/9 activities and the invasive capacity of the cancer cells
Santibáñez et al., FEBS Lett 2010
:
Furthermore,
MMP9 production was
MAPK dependent , as the MEK inhibitor PD98059 decreased TGF-beta1 induced MMP9 expression and secretion in Q61LRac1 expressing cells
Chen et al., Invest New Drugs 2011
(Breast Neoplasms) :
The
MAPK inhibitors effectively
prevented the loss of
MMP and apoptosis induced by protoapigenone
You et al., Mol Biol Rep 2011
:
All the
MAPK inhibitors slightly
enhanced cell growth inhibition, death and
MMP ( d?m ) loss, and increased ROS levels in PG-treated HeLa cells
Li et al., Proc Natl Acad Sci U S A 2010
(Dermatitis, Atopic) :
p38
MAPK induces
matrix metalloproteinase-2 expression to cleave E-cadherin, which mediates keratinocyte cohesion in the epidermis
Cui et al., Biochem Biophys Res Commun 2012
(Neoplasm Invasiveness) :
Subsequent functional validation revealed that K63E and S193A mutants, which disrupted CD147 dimerization both in solution and in living cells, showed clearly dominant negative effects on
MAPK activation,
MMP2 induction and invasiveness in tumor cells ... Subsequent functional validation revealed that K63E and S193A mutants, which disrupted CD147 dimerization both in solution and in living cells, showed clearly dominant negative effects on
MAPK activation,
MMP2 induction and invasiveness in tumor cells
Hsu et al., J Cell Physiol 2012
(Colonic Neoplasms) :
p38a
MAPK mediates 17ß-estradiol inhibition of
MMP-2 and -9 expression and cell migration in human lovo colon cancer cells ... After administration of inhibitors including QNZ ( NF?B inhibitor ), LY294002 ( Akt activation inhibitor ), U0126 ( ERK1/2 inhibitor ), SB203580 ( p38 MAPK inhibitor ) or SP600125 ( JNK1/2 inhibitor ), E ( 2 ) -downregulated cell migration and expression of
MMP-2 and MMP-9 in LoVo cells is markedly
inhibited only by p38
MAPK inhibitors, SB203580 ... Application of specific target gene siRNA ( ERa, ERß, p38a, and p38ß ) to LoVo cells further confirmed that p38
MAPK mediates E ( 2 ) /ERs inhibition of
MMP-2 and -9 expression and cell motility in LoVo cells
Du et al., Hum Reprod 2012
:
CsA up-regulated CXCL12 and CXCR4 expression in human first-trimester cytotrophoblast cells, but not in DSCs. Blocking the mitogen activated proteinkinase/extracellular signal regulated kinase (
MAPK/ERK1/2 ) signaling by U0126 abrogated the CsA induced increase in CXCL12 and CXCR4 expression and neutralizing antibodies to CXCL12 or CXCR4 completely
inhibited the CsA induced increase in cell number, invasion and MMP-9 and
MMP-2 activity of cytotrophoblast
Kinjo et al., Cytotechnology 2012
:
MMP-2 gene expression was only inhibited by SB203580 treatment, suggesting a pivotal
role of p38
MAPK in regulation of
MMP-2 gene expression
Lee et al., J Dermatol Sci 2013
:
In UVB irradiated HaCaT cells, 8-oxo-dG inhibited ROS production, subsequent
activation of
mitogen activated protein kinase ( MAPK ), ATF-2, and c-Jun, and
MMP expression
Yen et al., TheScientificWorldJournal 2013
(Gingival Neoplasms...) :
After CTXIII treatment, the
MMP-2 and MMP-9 protein expressions were downregulated, and the phosphorylation of JNK and
p38-MAPK was
increased independent of ERK phosphorylation
Pan et al., Mol Biol Rep 2013
(MAP Kinase Signaling System...) :
SDF-1a upregulation of
MMP-2 is
mediated by p38
MAPK signaling in pancreatic cancer cell lines
Seo et al., PloS one 2013
:
MS-enhanced
MMP-2 expression and activity were
inhibited by molecular inhibition of Akt using Akt siRNA as well as by PI3K/Akt inhibitors, LY293002 and AI, but not by
MAPK inhibitors such as PD98059, SP600125 and SB203580