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HIF1A — MMP9
Text-mined interactions from Literome
Luo et al., BJU Int 2006
(Neoplasm Invasiveness...) :
The expression of E-cadherin, vimentin, cathepsin D,
MMP-2 and uPAR, which are proteins with established roles in the pathophysiology of invasion, could be
regulated by
HIF-1alpha in human prostate cancer cells
Ding et al., Brain Res 2009
(Brain Injuries) :
Inhibition of
HIF-1alpha reduced expression of
MMP-2 and -9
Kang et al., Clin Exp Pharmacol Physiol 2009
(Diabetes Mellitus, Experimental...) :
Impairment of ischaemia induced EPC mobilization in the diabetic mouse model is associated with altered
HIF-1 alpha/VEGF and
MMP/TIMP regulation and represents a novel mechanism underlying defective postischaemic neovascularization in diabetes
Lee et al., J Cell Physiol 2010
:
Consequently, the increased
HIF-1alpha expression
induced activation of matrix metalloproteinase (MMP)-2 and
MMP-9