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MMP15 — MMP9

Text-mined interactions from Literome

Murphy et al., APMIS 1999 : Gelatinase A, collagenase 3 and gelatinase B may be activated by MT-MMP based mechanisms, as evidenced by both biochemical and cell based studies
Legrand et al., J Cell Biol 1999 : In vivo and in vitro, MMP-9 accumulated in migrating HBEC located at the leading edge of a wound and MMP-9 expression paralleled cell migration speed
Corbel et al., Eur J Pharmacol 2001 (Acute Disease...) : Batimastat did not reduce MMP secretion in BAL fluid but inhibited MMP-9 activity
Viitanen et al., Res Vet Sci 2001 (Foot Diseases...) : In contrast, the absolute HA concentration and HA/ COMP, MMP-2/COMP and MMP-9/COMP ratios were higher in synovial fluid from the DIP-joint of horses with navicular disease, and MMP-2 and MMP-9 relative activity levels and MMP-2/COMP and MMP-9/ COMP ratios were increased in fluid from navicular bursae in horses with navicular disease when compared to a control group
Mori et al., Blood 2002 (Leukemia-Lymphoma, Adult T-Cell...) : The biologic significance of these observations was validated by the following 2 findings : MMP-9 expression was increased in primary ATL cells, and plasma MMP-9 levels were elevated in ATL patients
Yeo et al., Arch Virol 2002 (Respiratory Syncytial Virus Infections) : Thus, this study concludes that although RSV infection induces MMP-9 , which can enhance the syncytia formation leading to RSV multiplication and spread it can be inhibited by MMP inhibitors
Eagleton et al., J Surg Res 2002 : Zymography demonstrated a dose dependent increase in 92-kDa MMP ( pro-MMP-9 ) activity ( P < 0.001 ) with corresponding increases in pro-MMP-9 protein ( P = 0.03 ) and mRNA levels ( P = 0.004 )
Yoshioka et al., J Periodontol 2003 : In this study, we evaluated the cytotoxicity of hydroxamic acid based MMP inhibitors ( ONO-4817, ONO-MI1-514, and ONO-MI1-570 ), and their inhibitory effects on MMP-2 and -9 activities and growth of Porphyromonas gingivalis
Lalu et al., Mol Cell Biochem 2003 (Cardiomyopathies...) : The MMP inhibitors significantly improved cardiac function of LPS treated rats ( Ro 31-9790 : 38 +/- 3, doxycycline : 51 +/- 3 mmHg*mL*min ( -1 ) ), had no effect on the loss of MMP-2 activity, and significantly reduced the MMP-9 activity in the perfusate
Johnson et al., Circ Res 2004 (Ischemia) : Our study indicates that angiogenesis triggered by tissue ischemia requires MMP-9 , which may be involved in capillary branching, a potential novel role for this MMP that could be exploited to control angiogenesis
Lorenzl et al., Neuromolecular Med 2004 (Disease Models, Animal...) : MMP-9 expression as measured via zymography in the substantia nigra was reduced by the MMP inhibitor
Kuivanen et al., J Cutan Pathol 2004 (Adenocarcinoma...) : MMP-7, MMP-13 , and MMP-19 were detected abundantly in MMPD, while MMP-9 was absent
Akahane et al., Exp Cell Res 2004 : Both recombinant human TIMP-1 and the synthetic MMP inhibitors, GM6001 and MMP-2-MMP-9 Inhibitor III, suppressed migration of human dermal microvascular endothelial cells ( HDMVEC ) in a dose dependent fashion
Mali et al., Invest Ophthalmol Vis Sci 2005 (Retinal Degeneration) : Furthermore, a synthetic MMP inhibitor inhibited KCl mediated MMP-9 upregulation, which led to a significant attenuation of KCl induced retinal damage
Moche et al., Pneumologie 2005 (Lung Neoplasms...) : MMP and TIMP plasma concentrations were not different in CA vs. CHF, but MMP-9 , TIMP-1, and TIMP-2 were increased vs. CON ( p < 0.005, each )
Bindhu et al., Head Neck 2006 (Carcinoma, Squamous Cell...) : MMP activation , particularly MMP2 and MMP9 , observed in different cancers, has been shown to be mediated via the transcription factor nuclear factor kappa B (NF-kappaB)
Kimata et al., Allergol Int 2006 : Glucocorticoids and flavonoids inhibited MMP-9 production, and TIMPs and MMP inhibitors inhibited the gelatinolytic activity of mast cell derived MMP-9
Zozulya et al., J Immunol 2007 : We show that DCs produce matrix metalloproteinases (MMP) -2 and -9 and GM6001, an MMP inhibitor , decreases both baseline and MIP-1alpha induced DC transmigration
Nguyen et al., J Neurochem 2007 (Brain Injuries...) : In accordance with protection by GM6001, conditioned media collected from MMP-9 null PMNs was less neurotoxic than that collected from wild-type PMNs. Additionally, MMP inhibition reduced PMN derived ROS ; removal of ROS reduced PMN derived MMP-9 activity ; and TNF-alpha inhibition reduced both PMN derived MMP-9 activity and ROS in PMN cultures
Zhou et al., Hum Reprod 2007 : CsA increased the invasive index of first-trimester human trophoblasts ( P < 0.01 ), as well as the messenger RNA, protein levels ( both P < 0.01 ) and proteolytic activity ( P < 0.05 ) of MMP-9 and MMP-U0126 , a mitogen activated protein/extracellular signal regulated kinase ( MEK ) inhibitor, inhibited the enhanced invasiveness and activity of MMP-9 and MMP-in these cells induced by CsA
Lee et al., Stroke 2007 (Cerebral Hemorrhage...) : We hypothesized that increased MMP-9 was associated with ICH induced by vascular endothelial growth factor hyperstimulation and that this effect could be attenuated by nonspecific MMP inhibition ... Effects of minocycline, a nonspecific MMP inhibitor, and pyrrolidine dithiocarbamate, an upstream regulator of MMPs, on MMP-9 activity and thereby the degree of ICH were also tested
Bonnema et al., J Card Fail 2007 : As subject age increased, MMP-2 increased ( from 1188 +/- 99 ng/mL to 1507 +/- 76 ng/mL ), MMP-7 increased ( from 1.2 +/- 0.1 ng/mL to 3.1 +/- 0.6 ng/mL ), MMP-9 decreased ( from 29 +/- 7 ng/mL to 8 +/- 2 ng/mL ), and TIMP-1, 2, and 4 increased ( from 728 +/- 46 ng/mL to 1093 +/- 73 ng/mL, from 34 +/- 5 ng/mL to 53 +/- 6 ng/mL, and from 1.26 +/- 0.22 ng/mL to 2.34 +/- 0.30 ng/mL, respectively ) ( all P < .05 )
Inamoto et al., Cancer Invest 2007 (Carcinoma, Renal Cell...) : It was noteworthy that the ras/raf/MEK/ERK pathway inhibitor PD98059 attenuated GABA induced MMP-9 expression and that both PD98059 and MMP inhibitors attenuated the GABA induced invasive activity of Caki-2 cells
Cheng et al., Mol Cell Biochem 2009 : Here, we show that LPS challenge increased the protein levels of uPA, MMP-2 and MMP-9, and induced the activity of MMP-2 and MMP-9 in H9c2 cardiomyoblasts
Murakami et al., Histol Histopathol 2009 (Dog Diseases...) : Although MMP-9 immunoreactivity was n't detected in neoplastic and active angiogenic endothelial cells ( ECs ), MMP-2 was detected in all ECs of GTs and in neoplastic cells of both vascular tumors
Yu et al., Cytotechnology 2009 : Matrine significantly reduced the invasion, MMP-9/MMP-2 activation , Akt phosphorylation, nuclear factor kappaB p-65 expression and DNA binding activity, and mRNA levels of MMP-9 , MMP-2, EGF and VEGFR1 in MDA-MB-231 cells
La et al., J Periodontol 2009 : Grape seed extract suppresses lipopolysaccharide induced matrix metalloproteinase ( MMP ) secretion by macrophages and inhibits human MMP-1 and -9 activities
Teles et al., Infect Immun 2010 (Inflammation...) : The participation of MMPs in disease was suggested by ( i ) increased MMP mRNA expression levels in skin biopsy specimens correlating with the expression of gamma interferon ( IFN-gamma ) and tumor necrosis factor alpha (TNF-alpha), ( ii ) the detection of the MMP protein and enzymatic activity within the inflammatory infiltrate, ( iii ) increased MMP levels in patient sera, and ( iv ) the in vitro induction of MMP-9 by Mycobacterium leprae and/or TNF-alpha
Ito et al., Biochem Biophys Res Commun 2010 (Disease Progression...) : In HT1080 cells, positive both in MT1-MMP and MT2-MMP , the migration as well as the invasion was impaired by MT1-MMP or MT2-MMP suppression
Shin et al., Neurochem Res 2010 : In this condition, uPA increased the activity of matrix metalloproteinase ( MMP-9 ) and the inhibition of MMP activity with pharmacological inhibitors against either uPA ( amiloride ) or MMP ( phenanthrolene and SB-3CT ) effectively prevented BV2 cell migration
Benson et al., Am J Respir Cell Mol Biol 2011 : Intracellular calcium flux was augmented in response to MMP inhibition or deficiency in the same cells, and IL-2 production was reduced in CD4 ( + ) and CD8 ( + ) MMP9 ( -/- ) T cells
Chen et al., Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2010 : The results showed : ( 1 ) The expression of MMP-9 was weak in static state, however, MMP-9 expression increased when MSCs were exposed to 15 dyne/cm2 shear stress for 2 hours, and MMP-9 expression increased with the extension of stimulating time, and it reached the peak at 24 h ; ( 2 ) MSCs were stimulated by shear stress for 2 hours at different strengths ( 5 dyne/cm2, 15 dyne/cm2, 30 dyne/cm2 ), and under all these conditions, the expression of MMP-9 increased, and reached the peak at 15 dyne/cm2 ; ( 3 ) After MSCs were pretreated by three kinds of signal pathway inhibitors, the expression of MMP-9 did not change obviously in Wortmannin group and PD98059 group, but it was significantly inhibited in SB202190 group
Feng et al., PloS one 2011 (Leukemia) : However, these alterations reduced when MMP-2 and -9 activities were inhibited by RNA interference strategy or by MMP inhibitor GM6001 in an in vitro BBB model
Kular et al., Journal of neuroinflammation 2012 (Disease Models, Animal...) : In vitro, results based on cultured DRG neurons showed that siRNA mediated inhibition of NOV enhanced IL-1ß- and TNF-a induced MMP-2, MMP-9 and CCL2 expression whereas NOV addition inhibited TNF-a induced MMP-9 expression through ß1 integrin engagement
Marquis et al., BMC complementary and alternative medicine 2012 (Periodontal Diseases) : We also investigated the capacity of these compounds to reduce cytokine and matrix metalloproteinase ( MMP ) secretion by lipopolysaccharide (LPS) stimulated macrophages and to inhibit MMP-9 activity
Fu et al., Ren Fail 2012 (Fibrosis) : The expressions of HIF-1a, TGF-ß1, MMP-9 , and TIMP-1 were elevated and MMp-9/TIMP-1 ratio was lowered in the model group ( p < 0.05 ), but losartan increased the expression of MMP-9 and MMp-9/TIMP-1 ratio ( p < 0.05 ) and lessened the expressions of HIF-1a, TGF-ß1, and TIMP-1 ( p < 0.05 )
Quan et al., Clin Exp Metastasis 2013 (Bone Neoplasms...) : Of factors associated with invasion, MMP-2 was unchanged and MMP-9 increased in SCC25 and Tca8113, while MMP-2 was increased and MMP-9 unchanged in HN5
Swamydas et al., Cell Adh Migr 2013 (Mammary Neoplasms, Animal...) : Additionally, the addition of specific MMP9/MMP13 and MMP14 inhibitors prevented the MMP activities of supernatants collected from 4T1 cells incubated with D1CM, CCL5 or CCL9
Imada et al., Biol Reprod 1997 : Thus, MMP-9 and progesterone are very likely to play essential roles in cervical ripening and dilatation in the rabbit, and the production of MMP-9 in the cervix is finely regulated during pregnancy