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IL3 — PI3

Text-mined interactions from Literome

Rosa Santos et al., Oncogene 2000 : These results indicate that the activations of STAT5 and the PI 3-kinase by IL-3 in Ba/F3 cells are tightly connected and cooperate to mediate IL-3 dependent suppression of apoptosis by modulating Bad phosphorylation and Bcl-x expression
Cruz et al., J Leukoc Biol 2005 : We show that S6K2 is activated by IL-3 in the IL-3 dependent Ba/F3 cell line and that this is mediated by mTOR and its upstream activator PI-3K but not by the MAPK kinase/extracellular signal regulated kinase pathway
Yu et al., J Biol Chem 2006 (Leukemia) : The E76K mutation in the N-terminal Src homology 2 domain increased interactions of mutant SHP-2 with Grb2, Gab2, and p85, leading to hyperactivation of IL-3 induced Erk and phosphatidylinositol 3-kinase (PI3K) pathways
Gold et al., J Biol Chem 1994 : We show that interleukin-3 (IL-3) , interleukin-4 (IL-4), interleukin-5 (IL-5), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and steel factor ( SLF ) all activate PI 3-kinase
Minshall et al., J Immunol 1996 : In this work, we show that IL-3 dependent FDCP-1/Mac-1 murine hemopoietic progenitors express receptors for another growth factor, insulin-like growth factor-I (IGF-I), and that both IL-3 and IGF-I stimulate PI 3-kinase activity ... To determine whether PI 3-kinase mediates IL-3- and IGF-I induced inhibition of apoptosis, FDCP-1/Mac-1 cells were incubated with the PI 3-kinase inhibitor, wortmannin
del Peso et al., Science 1997 : Akt, a survival promoting serine-threonine protein kinase, was activated by IL-3 in a PI 3-kinase dependent manner