Gene interactions and pathways from curated databases and text-mining

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FOS — IFI44

Text-mined interactions from Literome

Gao et al., Hepatology 1999 : HGF alone induced moderate levels of c-Jun-N-terminal kinase (JNK) and p44/p42 mitogen activated protein kinase ( MAPK ), resulting in moderate levels of AP-1-DNA binding activity
Mendes et al., Nitric Oxide 2002 : Finally, the p42/44MAPK inhibitor, PD 98059, prevented IL-1 induced AP-1 activation in a concentration that did not inhibit iNOS expression
Tu et al., Cardiovasc Toxicol 2003 : Distinct roles of p42/p44 ( ERK ) and p38 MAPK in oxidant induced AP-1 activation and cardiomyocyte hypertrophy
Fradette et al., Curr Drug Metab 2004 (Anoxia...) : The up-regulation of CYP3A6 implies a PTK- and p42/44MAPK dependent stabilization/activation, nuclear translocation of HIF-1 and AP-1 , binding to CYP3A6 promoter, and transactivation of the gene to induce CYP3A6 expression
Englaro et al., J Biol Chem 1995 (Melanoma, Experimental) : In an attempt to connect these molecular events to the control of tyrosinase expression that appears to be the pivotal point of melanogenesis regulation, we hypothesized that following its activation by cAMP, p44mapk activates AP-1