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BNIP3 — HIF1A
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Guo et al., Cell Death Differ 2001
:
Overexpression of
HIF1alpha , but not p53,
induces the expression of
BNIP3
Vengellur et al., Toxicological sciences : an official journal of the Society of Toxicology 2004
:
These experiments document that
BNip3 and NIX expression is
HIF1alpha dependent , and cobalt induces their expression in a time and dose dependent manner
Zhang et al., Free Radic Biol Med 2007
:
HIF-1alpha activation by a redox-sensitive pathway mediates cyanide
induced BNIP3 upregulation and mitochondrial dependent cell death
Benson et al., J Bone Joint Surg Br 2010
(Shoulder Impingement Syndrome...) :
Biopsies were analysed using three immunohistochemical techniques, namely antibodies against HIF-1alpha ( a transcription factor produced in a hypoxic environment ),
BNip3 ( a
HIF-1alpha regulated pro-apoptotic protein ) and TUNEL ( detecting DNA fragmentation in apoptosis )
Menrad et al., Hepatology 2010
(Carcinoma, Hepatocellular...) :
Furthermore, an HIF-2alpha-knockdown significantly increased Bcl-2/adenovirus
E1B 19 kDa interacting protein 3 (BNIP3) expression in an
HIF-1alpha dependent manner
Chiavarina et al., Cell cycle (Georgetown, Tex.) 2010
(Breast Neoplasms...) :
Activated
HIF1a also
induced BNIP3 and BNIP3L expression, markers for the autophagic destruction of mitochondria