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COL4A2 — MMP15
Text-mined interactions from Literome
Ahmed et al., J Cell Biochem 2002
(Ovarian Neoplasms) :
Plasminogen dependent [ 3H ]
-collagen IV degradation was
inhibited by inhibitor of uPA ( amiloride ) and
MMP ( phenanthroline ) and by antibodies against uPA or MMP-9 or alphavbeta6 integrin, indicating the involvement of alphavbeta6 integrin, uPA and MMP-9 in the process
Altincicek et al., Dev Comp Immunol 2008
:
Recently, we postulated that an endogenous
MMP expressed in the lepidopteran model Galleria mellonella during metamorphosis
causes degradation of
collagen-IV , which in turn results in activation of innate immunity
Rebustini et al., Dev Cell 2009
:
Specifically, reducing epithelial
MT2-MMP profoundly decreases proliferation and morphogenesis,
increases Col4a2 and intracellular accumulation of collagen IV, and decreases the proteolytic release of collagen IV NC1 domains