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CLOCK — SERPINE1

Text-mined interactions from Literome

Maemura et al., J Biol Chem 2000 : Furthermore, Period2 and Cryptochrome1, whose expression show a circadian oscillation in peripheral tissues, inhibit the PAI-1 promoter activation by the CLOCK : CLIF heterodimer
Maemura et al., Ann N Y Acad Sci 2001 (Myocardial Infarction) : Furthermore, Period and Cryptochrome, which are negative regulators in the feedback loop of the biological clock, inhibited PAI-1 promoter activation by the CLOCK : CLIF heterodimer
Oishi et al., Journal of thrombosis and haemostasis : JTH 2006 (Obesity) : CLOCK is involved in obesity induced disordered fibrinolysis in ob/ob mice by regulating PAI-1 gene expression ... These observations suggest that CLOCK is involved in obesity induced disordered fibrinolysis by regulating PAI-1 gene expression in a tissue dependent manner
Oishi et al., Mol Pharmacol 2010 : Luciferase reporter and chromatin immunoprecipitation analyses using primary hepatocytes demonstrated that DNA binding of both PPARalpha and CLOCK is essential for bezafibrate induced PAI-1 gene expression