◀ Back to GNA12
GNA12 — JUN
Text-mined interactions from Literome
Dermott et al., Oncogene 2004
(Cell Transformation, Neoplastic) :
Using this model system, our previous studies have shown that the stimulation of
Galpha(12)WT or the expression of an activated mutant of Galpha(12) ( Galpha(12)QL )
leads to increased cell proliferation and subsequent oncogenic transformation of NIH3T3 cells, as well as persistent activation of
Jun N-terminal kinases (JNKs)
Collins et al., J Biol Chem 1996
:
Transient expression of activated
Galpha12 increased the percentage of Ras in the active, GTP bound state,
stimulated c-Jun NH2-terminal kinase (JNK) activity, and enhanced the transcriptional activity of c-Jun
Collins et al., Oncogene 1997
(Astrocytoma) :
Expression of the SH2 domain of Shc also inhibits
G alpha12 mediated induction of an
AP-1 dependent reporter gene demonstrating that G12 utilizes Shc to propagate downstream signals