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EPHA2 — RHOA
Pathways - manually collected, often from reviews:
-
NCI Pathway Database EPHA forward signaling:
Ephrin A1/EPHA1-4/Ephexin complex (EFNA1-EPHA2_EPHA1_EPHA3_EPHA4-NGEF)
→
RHOA/GTP complex (RHOA)
(modification, activates)
Shamah et al., Cell 2001
Evidence: mutant phenotype, assay
-
NCI Pathway Database EPHA forward signaling:
Ephrin A1/EPHA1-4/Ephexin complex (EFNA1-EPHA2_EPHA1_EPHA3_EPHA4-NGEF)
→
RHOA/GDP complex (RHOA)
(modification, activates)
Shamah et al., Cell 2001
Evidence: mutant phenotype, assay
-
NCI Pathway Database EPHA2 forward signaling:
Ephrin A1/EPHA2 complex (EFNA1-EPHA2)
→
RHOA/GDP complex (RHOA)
(modification, activates)
Fang et al., J Cell Sci 2008
Evidence: mutant phenotype, assay
-
Reactome Reaction:
EPHA2
→
RHOA
(reaction)
Wahl et al., J Cell Biol 2000, Dickson et al., Curr Opin Neurobiol 2001, Sahin et al., Neuron 2005
Text-mined interactions from Literome
Winning et al., Differentiation 2002
:
These data argue that, in contrast to the case in retinal ganglion cells,
EphA4 in early Xenopus embryos acts to
inhibit RhoA , suggesting that this receptor may regulate Rho differently ( and therefore affect the cytoskeleton differently ) in neuronal and non-neuronal cells
Fang et al., J Cell Sci 2008
:
By contrast,
RhoA GTPase activity was significantly
affected by modulating the
EPHA2 activity in MCF-10A cells