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GNA13 — RHOA

Pathways - manually collected, often from reviews:

• NCI Pathway Database PAR1-mediated thrombin signaling events: RHOA/GDP complex (RHOA) → G13/GTP/p115RhoGEF complex (GNA13-ARHGEF1) (modification, collaborate)
  Moers et al., Nat Med 2003, Huang et al., J Biol Chem 2007*
  Evidence: mutant phenotype, assay
• NCI Pathway Database CXCR4-mediated signaling events: RhoA-B-C/GDP complex (RHOC_RHOA_RHOB) → G13/GTP complex (GNA13) (modification, collaborate) Tan et al., J Biol Chem 2006
  Evidence: mutant phenotype, assay
• NCI Pathway Database PAR4-mediated thrombin signaling events: RHOA/GDP complex (RHOA) → G13/GTP complex (GNA13) (modification, collaborate) Moers et al., Nat Med 2003
  Evidence: genetic interaction, other species
• NCI Pathway Database Plasma membrane estrogen receptor signaling: RHOA/GDP complex (RHOA) → G13/GTP complex (GNA13) (modification, collaborate) Simoncini et al., Mol Endocrinol 2006
  Evidence: mutant phenotype
• NCI Pathway Database S1P2 pathway: S1P/S1P2/G12/G13 complex (S1PR2-GNA12-GNA13) → RhoA (RHOA) (modification, activates) Okamoto et al., Mol Cell Biol 2000*, Sugimoto et al., Mol Cell Biol 2003, Ikeda et al., Biochem Biophys Res Commun 2004*, Gonda et al., Biochem J 1999

Text-mined interactions from Literome

Jin et al., Biochem Biophys Res Commun 2000 : Activation of RhoA by association of Galpha(13) with Dbl
Wells et al., J Biol Chem 2002 : Deletions in the N terminus of the protein eliminate GAP activity but retain substantial binding to Galpha(13) and activation of RhoA exchange activity by Galpha(13)
Xie et al., J Biol Chem 2002 : However, the RhoA-insensitive mutants, rPLD1 ( K946A, K962A ) and rPLD1 ( K962Q ), were not activated by Galpha(13)Q226L , although these mutant enzymes responded to phorbol ester and Galpha ( q ) Q209L
Booden et al., Mol Cell Biol 2002 : Activated G alpha q, as well as G alpha 12 and G alpha 13 , cooperated with LARG and caused synergistic activation of RhoA , suggesting that all three G alpha subunits stimulate LARG mediated activation of RhoA
Lutz et al., J Biol Chem 2005 : We further demonstrate that active G alpha ( q ) or G alpha11, but not G alpha12 or G alpha13 , strongly enhances p63RhoGEF induced RhoA activation by direct protein-protein interaction with p63RhoGEF at its C-terminal half
Liu et al., J Biol Chem 2005 : By contrast, Galpha(13)Q226L activated RhoA but not Rac1 or Cdc42
Zhang et al., Cell Signal 2007 : Previous studies have shown that the cellular signaling elicited by LPA results in activation of the small GTPase RhoA by Galpha(12/13) - as well as Galpha ( q ) -dependent pathways
Rojas et al., J Biol Chem 2007 : Although studies have elucidated mechanisms governing Galpha(12/13) mediated RhoA activation, proteins that functionally couple Galpha ( q/11 ) to RhoA activation have remained elusive
Bartolomé et al., Cancer Res 2008 (Lung Neoplasms...) : The data indicate that G(alpha)(13) dependent downstream effects on RhoA activation and invasion tightly depend on cell type-specific GAP activities and that G(alpha)(13)-p190RhoGAP signaling might represent a potential target for intervention in melanoma metastasis
Ponsioen et al., Mol Biol Cell 2009 : CLIC4 recruitment is strictly dependent on Galpha(13) mediated RhoA activation and F-actin integrity, but not on Rho kinase activity ; it is constitutively induced upon enforced RhoA-GTP accumulation
Sabbatini et al., Am J Physiol Cell Physiol 2010 : Using specific assays for RhoA and Rac1 activation, we showed that only active Galpha(13) activated RhoA