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IFNB1 — IRF6

Text-mined interactions from Literome

Sing et al., Infect Immun 2000 : For this purpose, the IFN-beta and other macrophage cytokine responses induced by LPS and several killed gram negative and gram positive bacteria in LPS-sensitive ( Lps-normal [ Lps ( n ) ] ; C57BL/10ScSn and BALB/c ) and Lps ( d) (C57BL/10ScCr and BALB/c/l ) mice in vitro and in vivo were investigated on the mRNA and protein levels ... LPS and all gram negative bacteria employed induced IFN-beta in the Lps ( n ) mice but not in the Lps ( d ) mice
Crespo et al., Biochem J 2000 : IFN-alpha/beta is one of these mediators, but plays only a partial role in the induction of SOCS-1 because neutralization of LPS induced IFN-alpha/beta production incompletely inhibits the induction of SOCS-1
Park et al., Int J Lepr Other Mycobact Dis 2000 : These data indicate a pivotal role for IFN-gamma and IFN-beta for the production of LPS and LAM initiated NO in peritoneal macrophages from low-responder ( C3H/HeJ ) mice
Inoue et al., J Rheumatol 2001 (Arthritis, Experimental...) : LPS induced IFN-beta and IRF-1 gene expression were markedly suppressed by KE-758
Remoli et al., J Immunol 2002 : Once expressed, IRF-1 may further stimulate the transcription of IFN-beta
Karaghiosoff et al., Nat Immunol 2003 (Shock, Septic) : Toll-like receptor-4 activation by lipopolysaccharide (LPS) induces the expression of interferon-beta (IFN-beta) in a MyD88 independent manner ... Basal and LPS induced expression of IFN-beta and IFN-alpha4 mRNA in Tyk2-null macrophages were diminished
Sakaguchi et al., Biochem Biophys Res Commun 2003 : Although much has been studied about the activation of the transcription factor IRF-3 and induction of IFN-beta gene by the LPS mediated TLR4 signaling, definitive evidence is missing about the actual role of IRF-3 in LPS responses in vitro and in vivo ... Using IRF-3 deficient mice, we show here that IRF-3 is indeed essential for the LPS mediated IFN-beta gene induction
Toshchakov et al., J Endotoxin Res 2003 : The data presented show that activation of TLR4 by Escherichia coli LPS results in an MyD88 independent, TIRAP/Mal dependent signaling pathway that, in turn, leads to early induction of interferon-beta (IFN-beta)
Oshiumi et al., J Biol Chem 2003 : We conclude that for LPS-TLR4 mediated activation of IFN-beta , the adapter complex of TICAM-2 and TICAM-1 plays a crucial role
Yamamoto et al., Mol Immunol 2004 : However, recent studies using MyD88-deficient mice have revealed that some TLRs possess a MyD88 independent pathway, which is represented by interferon (IFN)-beta production induced by LPS stimulation
Coccia et al., Eur J Immunol 2004 : TLR-9 stimulation by CpG DNA induced the expression of all IFN-alpha, -beta, -omicron and -lambda subtypes in pDC, whereas TLR-4 stimulation by LPS , or TLR-3 stimulation by poly I:C, induced only IFN-beta and IFN-lambda gene expression in MDDC
Marson et al., J Biol Chem 2004 (Inflammation) : These IRF3 activities have been shown to be essential for the initiation of transcription of the IFNbeta gene, and the loss of these activities presumably accounts for the lack of LPS induced IFN beta transcription seen in the OxLDL pre treated cells
Kato et al., J Immunol 2004 : Further analysis demonstrated that addition of LPS binding protein (LBP), but not of soluble CD14 to the serum-free medium enabled the induction of IFN-inducible genes and IFN-beta itself by LPS in human monocytes ... This critical role for LBP implies the presence of possible mechanisms linking LBP to the intracellular signaling between Toll-like receptor 4 and IRF-3, leading to the induction of IFN-beta by LPS
Hemmi et al., J Exp Med 2004 (Virus Diseases) : TBK1-deficient embryonic fibroblasts (EFs) showed dramatic decrease in induction of IFN-beta and IFN-inducible genes in response to LPS or dsRNA as well as after viral infection
Kamezaki et al., Int Immunol 2004 (MAP Kinase Signaling System...) : In Stat1-deficient mice, the induction of IFN-beta by LPS in macrophages was severely reduced, although the serum level of IFN-gamma was elevated after LPS injection ... In contrast, in Stat-4 deficient mice, the induction of IFN-beta by LPS was normal, but the serum level of IFN-gamma remained low after LPS injection ... Interestingly, the induction of both IFN-beta and IFN-gamma by LPS was severely reduced in Tyk2-deficient mice
Tebo et al., J Immunol 1992 : Thus, even though LPS is a potent inducer of IFN-beta in murine macrophages, class I IFN expression may not be an obligatory intermediate event in the LPS-driven activation of ISRE binding activity
Sugiyama et al., Microbiol Immunol 2004 : 2-AP also reduced the expression of IFN-beta and IFN-inducible genes, such as IFN-gamma-inducible protein ( IP ) -10 and immune-responsive gene (IRG)-1, and the inducible type of NO synthase (iNOS) mRNA in response to LPS ... These results suggested that 2-AP inhibited LPS induced IFN-beta production by preventing Toll/IL-1 receptor domain containing adaptor inducing IFN-beta ( TRIF ) -dependent signaling rather than myeloid differentiation factor (MyD) 88-dependent signaling, resulting in the inhibition of NO production
Shirota et al., J Immunol 2005 (Shock, Septic) : Underlying this protective effect is the ability of suppressive ODN to bind to and prevent the phosphorylation of STAT1 and STAT4, thereby blocking the signaling cascade mediated by LPS induced IFN-beta and IL-12
Shimomura-Shimizu et al., Biochem Biophys Res Commun 2005 : These chemicals also inhibited LPS induced interferon-beta (IFN-beta) expression, an indispensable factor for LPS induced iNOS expression
Hahn et al., J Virol 2005 (Leukoplakia, Hairy) : However, IRF-7 dependent activity of the IFN-alpha4, IFN-beta , and Tap-2 promoters, as well as an ISRE promoter construct, was inhibited by BZLF-1
Qin et al., Blood 2005 : These results indicate that both LPS induced NF-kappaB activation and endogenous production of IFN-beta that subsequently induces STAT-1alpha activation play critical roles in the transcriptional activation of the CD40 gene by LPS
Youn et al., J Immunol 2005 : The activation of IFN regulatory factor 3 and the expression of IFN-beta induced by LPS , poly ( I:C ), or TRIF were also suppressed by resveratrol
Ito et al., Int Immunol 2005 : In contrast, IFN-beta and nitric oxide were induced by LPS but not by rLSO530, rLSO483 or PGN
Equils et al., Clin Exp Immunol 2006 : 1,25- ( OH ) 2 D3 pretreatment of HMEC did not block MyD88 independent LPS induced interferon (IFN)-beta promoter activation
Mahieu et al., Proc Natl Acad Sci U S A 2006 (Disease Susceptibility...) : In vivo IFN-beta induction by LPS or influenza virus is very low in SPRET/Ei mice, but IFN-beta-treatment restores the sensitivity to LPS, and IFN type 1 receptor-deficient mice are also resistant to LPS
Thomas et al., J Biol Chem 2006 : Collectively, these findings reveal unanticipated regulatory roles for IFN-beta in response to LPS in vitro and in vivo
Kim et al., J Pharmacol Exp Ther 2007 : THI 53 also inhibited LPS mediated interferon (IFN)-beta production and nuclear factor-kappaB (NF-kappaB) activation
Qin et al., J Immunol 2006 : We previously demonstrated that LPS induction of CD40 in macrophages/microglia involves both NF-kappaB activation and LPS induced production of IFN-beta , which subsequently activates STAT-1alpha ... IL-10 inhibits LPS induced IFN-beta gene expression and subsequent STAT-1alpha activation, but does not affect NF-kappaB activation
Bagchi et al., J Immunol 2007 : Pretreatment with a D-specific agonist augmented LPS induced IFN-beta production
Azuma et al., Biochem Biophys Res Commun 2007 : Although the functional mechanism whereby extra-cellular BPI modulates the intra-cellular signal pathways selected by the TLR adaptors, MyD88 and TICAM-1 ( TRIF ), remains unknown, we infer that the lipid A portion of LPS participates in LBP amplified IFN-beta induction and that BPI binding to LPS leads to inhibition of the activation of NF-kappaB and IFN-beta by LPS or agonistic lipid A via TLR4 in an extrinsic mode
Wang et al., Blood 2007 : Here we demonstrate that Rab7b can negatively regulate lipopolysaccharide (LPS) induced production of tumor necrosis factor (TNF)-alpha, IL-6, nitric oxide, and IFN-beta , and potentiate LPS induced activation of mitogen activated protein kinase, nuclear factor kappaB, and IFN regulatory factor 3 signaling pathways in macrophages by promoting the degradation of TLR4
Ock et al., J Neurosci Res 2007 (Inflammation) : Hypoxia, however, differentially regulated MyD88 dependent and -independent pathways of TLR4 signaling : Hypoxia enhanced lipopolysaccharide (LPS) induced interferon regulatory factor-3 (IRF-3) activation and the subsequent expression of IFNbeta ( MyD88 independent pathway ), whereas it suppressed LPS induced NF-kappaB activation ( MyD88 dependent pathway )
Yasuda et al., J Immunol 2007 (Lupus Erythematosus, Systemic) : As anticipated, IFN regulatory factor (IRF)7 is required for IFN-alpha and IFN-beta production ... Unexpectedly, however, IRF5 plays a critical role in IFN-alpha and IFN-beta production induced not only by RNA containing immune complexes but also by conventional TLR7 and TLR9 ligands
Sauter et al., Vet Immunol Immunopathol 2007 : Induction of IFN bioactivity was not observed in doubly transduced HEK293 cells, and no evidence for IFN-beta mRNA induction in response to LPS was obtained, although cells responded by IFN-beta mRNA expression to stimulation by Sendai virus and poly-inosinic acid-poly-cytidylic acid ( poly ( I:C ) )
Tzung et al., Cancer Immunol Immunother 1991 : This endogenous IFN alpha/beta production by Kupffer cells was not induced by LPS because ( a ) addition of polymyxin B did not abolish the positive effects of anti-IFN alpha/beta antibody on nonparenchymal liver cells, and ( b ) similar results were obtained when comparing the responses of LPS-responsive C3HeB/FeJ and LPS-hyporesponsive C3H/HeJ mice
Bafica et al., J Immunol 2007 (Endotoxemia) : In this study, we demonstrate that induction of LRG47 by LPS is not dependent on MyD88 signaling, but rather, requires STAT-1 and IFN-beta ... In contrast, LPS induced phosphorylation of IFN regulatory factor-3 and expression of IFN-beta or the type I IFN regulated genes, CCL5 and CCL10, were unaltered in LRG47 ( -/- ) cells
Rui et al., J Immunol 2007 : In this study, we demonstrate that PECAM-1 ligation with CD38-Fc fusion protein negatively regulates LPS induced proinflammatory cytokine TNF-alpha, IL-6, and IFN-beta production by inhibiting JNK, NF-kappaB, and IFN regulatory factor 3 activation in macrophages
Zhou et al., J Immunol 2007 (Bacteroidaceae Infections) : However, the unique induction of IFN-beta by P. gingivalis LPS requires TLR7 and IFNalphabetaR cosignaling, and the induction of ISRE containing gene is dependent on the activation of IFN-beta autocrine loop
Eskan et al., J Immunol 2008 : We demonstrate that the expression of both IFN-beta and IFN-inducible protein-10 ( CXCL-10 ) is significantly up-regulated by LPS and S1P or LPS and a specific S1P1 agonist
Xu et al., J Immunol 2008 (Endotoxemia) : We demonstrate that PGE ( 2 ) strongly suppresses LPS induced IFN-beta production at the mRNA and protein levels ... The inhibitory effect of PGE ( 2 ) on LPS induced IFN-beta expression is mediated through PGE ( 2 ) receptor subtypes EP ( 2 ) and EP ( 4 ), and mimicked by the cAMP analog 8-Br-cAMP as well as by the adenylyl cyclase activator forskolin
Reimer et al., J Leukoc Biol 2008 : LPS induced a strong IFN-beta mRNA response within a short time-frame, which subsided at 8 h
Kotla et al., Virology 2008 : The type I interferon ( IFN ) response requires the coordinated activation of the latent transcription factors NF-kappaB, IRF-3 and ATF-2 which in turn activate transcription from the IFN-beta promoter
Kawanishi et al., Cell Biochem Funct 2008 : To clarify the effect of LPS on MCP-1 production in skeletal muscle cells, C2C12 cells from a mouse skeletal muscle cell line, and RAW 264.7 cells from a mouse macrophage cell line, were used to assess production of LPS induced MCP-1, nitric oxide ( NO ) and interferon (IFN)-beta ... LPS stimulation neither induced production of NO nor of IFN-beta , which is an NO inducer
Wang et al., J Immunol 2008 (Salmonella Infections, Animal) : We show here that LPS induces retinoic acid-inducible gene-I (RIG-I) in vitro and in vivo as a result from autocrine secretion of IFN-beta in macrophages
Yu et al., Mol Cell Biochem 2008 : Although LPS- and PGN induced cytokine secretions were decreased greatly by MyD88 downregulation, IFN-gamma induced protein-10 ( IP10 ) and IFNbeta expression were enhanced by LPS irrespective of the downregulation of MyD88
Schröder et al., EMBO J 2008 : Here, we describe a novel VACV protein, K7, which can inhibit PRR induced IFN-beta induction by preventing TBK1/IKKepsilon mediated IRF activation ... Therefore, this study shows for the first time the involvement of a DEAD box helicase in TBK1/IKKepsilon mediated IRF activation and Ifnb promoter induction
Wang et al., J Clin Invest 2009 (Enterocolitis...) : However, LPS induced IFN-beta expression, a TRAM/TRIF dependent response activated by TLR4, was reduced by Hfe deficiency
Sugiyama et al., Toxicol Lett 2010 : DON or NIV inhibited LPS induced expression of interferon-beta (IFN-beta) , which plays an indispensable role in LPS induced iNOS expression ... These results indicate that DON and NIV inhibit the LPS induced NO and IFN-beta production, which both play an important role for host protection against invading pathogens, and suggests that the inhibition of these factors may be involved in the immunotoxic effects of these mycotoxins
He et al., J Cell Biochem 2010 : The activation of TLR4 by LPS modulated the expression of TLRs, induced the phosphorylation of NF-kappaB, P38, and ERK42/44, and up-regulated the gene expression of cytokines IL-8, IFN-alpha, IFN-beta , and TNF-alpha, suggesting EPCs expressed functional TLR4
D'Addario et al., J Virol 1990 (Cell Transformation, Viral...) : TNF-alpha and IL-1 beta but not IFN-alpha or IFN-beta transcripts were induced by LPS
Gessani et al., J Virol 1989 : These cells are induced to secrete IFN-beta by LPS but not by IFN-gamma, suggesting that this cytokine may elicit such specific response only in PM. IFN-beta mRNA is undetectable in untreated RAW 264.7 cells, and accumulation of this mRNA is induced by LPS but not by IFN-gamma
Tabibzadeh et al., J Immunol 1989 : However, in contrast to peripheral blood monocytes and fibroblasts, bacterial LPS did not induce IFN-beta 2/IL-6 production in endometrial stromal cells
Helfgott et al., J Exp Med 1987 : E. coli derived LPS enhances IFN-beta 2 mRNA expression in FS-4 fibroblasts at a concentration as low as 0.3 ng/ml ; this response is near-maximal in the range of 0.1-1 microgram/ml LPS ... The increase in IFN-beta 2 mRNA level caused by LPS in FS-4 cells is detected within 30 min after addition of LPS , is sustained for at least 20 h thereafter, appears to involve the protein kinase C signal transduction pathway, does not require new protein synthesis, and is inhibited by dexamethasone in a dose dependent fashion ( in the range 10 ( -6 ) -10 ( -8 ) M )
Blanchard et al., J Immunol 1986 : These data demonstrate that LPS , which predominantly induces IFN-alpha/beta in fresh murine splenocytes, is able to stimulate T lymphocytes to produce IFN-gamma if the T cells are first exposed to endogenously produced or exogenously applied IL 2
Ding et al., J Immunol 1987 : This suggests that IFN alpha and/or IFN beta induced by LPS also contributed to inhibition of activation by rIFN gamma
Onozaki et al., J Immunol 1988 : Northern blot analysis using cDNAs for murine IFN-beta1 or human IFN-beta2 showed an increased expression of mRNA for IFN-beta1 but not for IFN-beta2 by stimulation with TNF or LPS, strongly suggesting that IFN-beta 1 rather than IFN-beta 2 is responsible for TNF or LPS effects
Nakane et al., Microbiol Immunol 1985 (Listeriosis) : IFN-gamma induction by LPS was markedly suppressed in mice in which IFN-alpha/beta produced by Listeria infection itself had been depleted by treatment with anti-mouse IFN-alpha/beta antibody, but it was not inhibited in mice when IFN-alpha/beta induced not by Listeria infection but by LPS had been depleted by treatment with anti-mouse IFN-alpha/beta antibody
Fujihara et al., J Biol Chem 1994 : These data thus suggest that endogenous IFN-beta , but not TNF-alpha, produced by LPS stimulated J774 cells specifically contributes , probably in an auto/paracrine fashion, to the activation of the i-NOS gene expression by LPS
Kimura et al., Am J Physiol 1994 (Acute-Phase Reaction) : The primary distinctions between LPS and poly I:C with respect to cytokine induction in the RAW 264.7 macrophage cell line were that LPS failed to induce interferon ( IFN ) -alpha, poly I:C induced interleukin (IL)-6 mRNA minimally and for a shorter time period than did LPS, and LPS induced IL-1 alpha and IFN-beta more rapidly than did poly I:C. ( ABSTRACT TRUNCATED AT 250 WORDS )
Heike et al., Mol Immunol 1994 : GM-CSF and IFN-beta genes were expressed in response to PMA/A23187, poly ( I ) : poly ( C ), IL-1 alpha, forskolin, or LPS stimulation in differentiated P19 cells, whereas IL-3 and IL-4 genes were not expressed
Krakauer et al., J Gen Virol 1993 : Neither interferon alpha ( IFN-alpha ) nor IFN-beta were detected in supernatants from THP-1 cells after the addition of LCMV, LPS , or LPS plus LCMV
Hattori et al., Biochem Mol Biol Int 1996 : In contrast, expression of IFN-beta and IRF-1 genes in response to LPS was potentiated in the presence of CHX
Liu et al., J Immunol 1998 : IFN-beta induces IL-1Ra and augments LPS- and IL-4 induced IL-1Ra, but suppresses LPS- and IL-1 induced IL-1, shifting the balance toward the expression of the IL-1Ra