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EGR1 — PDGFB

Text-mined interactions from Literome

Houston et al., Biochem Biophys Res Commun 2001 : NAB2 blocks Egr-1 activation of the tissue factor ( TF ) promoter, Egr-1 stimulated production of PDGF-AB , HGF, TGFbeta(1), and VEGF and the endogenous expression of PDGF-AB and TGFbeta(1)
Kamimura et al., Hypertension 2004 (Arteriosclerosis...) : This study examined intracellular signaling pathways leading to TF expression and Egr-1 activation , a key element in tissue factor transcription, by PDGF-BB in rat SMCs. PDGF-BB induced TF mRNA and protein expression in a time dependent manner ... Early growth response factor-1 (Egr-1) binding activity was also induced by PDGF-BB , as well as phosphorylation of extracellular signal regulated kinase ... PDGF-BB induced Egr-1 activation was suppressed by inhibitors of 2 upstream activators of Egr-1, extracellular signal regulated kinase ( ERK ) and Src family kinases, whereas antioxidants, phosphatidylinositol 3-phosphate kinase, and p38 MAPK inhibitors had no effect
Li et al., Zhonghua Gan Zang Bing Za Zhi 2005 : Stimulation of HSC by Aldo results in activation of EGR-1 via ERK1/2 pathway, leading to up-regulation of PDGF-B expression
Liu et al., Zhonghua Yi Xue Za Zhi 2005 (Graft Occlusion, Vascular...) : The activation and expression of Egr-1, PDGF-B , and TGF-beta(1) depend on Egr-1 and may contribute to the high expression of Egr1 via a feedback mechanism
Li et al., Nan Fang Yi Ke Da Xue Xue Bao 2008 : Stimulation of the HSCs with AngII results in EGR-1 activation via the ERK1/2 pathway, leading to up-regulation of PDGF-B expression
Sabuda-Widemann et al., Nephrol Dial Transplant 2009 : Mycophenolic acid inhibits the autocrine PDGF-B synthesis and PDGF-BB induced mRNA expression of Egr-1 in rat mesangial cells ... MPA strongly inhibited the PDGF-BB induced mRNA expression of Egr-1 decreasing to 7.6 +/- 2.5 % after 30 min ( P < or= 0.001 ) and to 4.7 +/- 3.1 % after 1 h ( P < or= 0.05 ), both being compared to the maximal expression induced by PDGF-BB ... The inhibitory MPA effect on PDGF-BB induced PDGF-B expression was not significantly restored by guanosine ( 56 +/- 18 % versus 32 +/- 17 % after 2 h, n.s. ), and MPA inhibition of PDGF-BB induced Egr-1 expression was not reversed by exogenous guanosine
Bethel-Brown et al., J Immunol 2011 : Furthermore, PDGF-BB induction was regulated by activation of ERK1/2 and JNK signaling pathways and the downstream transcription factor early growth response 1
Chen et al., Mol Cell Biochem 2012 : Our results suggest that CBP might be one of the main interaction targets for Egr-1, and the transient activation of Egr-1 and recruitment of CBP are required for thrombin induced PDGF-B in ECs