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HGF — PRKCB

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: PRKCB → HGF (increases)
  Evidence: HGF stimulates the cell invasion through PKC-alpha and PKC-beta1. GO 6973 inhibits HGF stimulated Caco-2 cell invasion by 28%.
• OpenBEL Selventa BEL large corpus: PRKCB → HGF (decreases) Ma et al., Br J Cancer 2007*
  Evidence: In c-MET-overexpressing SCLC cell line NCI-H69, hepatocyte growth factor (HGF) dramatically induced c-MET phosphorylation at phosphoepitopes pY1230/1234/1235 (catalytic tyrosine kinase), pY1003 (juxtamembrane), and also of paxillin at pY31 (CRKL-binding site). We utilised a global proteomics phosphoantibody array approach to identify further c-MET/HGF signal transduction intermediates in SCLC. Strong HGF induction of specific phosphorylation sites in phosphoproteins involved in c-MET/HGF signal ...