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AKT1 — FGB

Text-mined interactions from Literome

Reséndiz et al., Journal of thrombosis and haemostasis : JTH 2007 : In contrast, PAR4 partially sustained Akt phosphorylation independently of P2Y(12) and PI3K for up to 300 s. Pharmacologic inhibition of Akt reduced P-selectin expression and fibrinogen binding in platelets stimulated through PAR1, and delayed platelet aggregation in response to submaximal PAR1 or PAR4 stimulation, although aggregation at 300 s was unaffected
Rauch et al., Eur J Pharmacol 2007 : ICAM-1 antibodies inhibited fibrinogen induced Akt and p38 phosphorylation
Ryu et al., Journal of thrombosis and haemostasis : JTH 2009 (Neurodegenerative Diseases) : In microglia, fibrinogen mediates activation of Akt and Rho via the CD11b/CD18 integrin receptor, while in neurons fibrinogen induces phosphorylation of epidermal growth factor (EGF) receptor via the alphavbeta3 integrin