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AKT1 — NPY6R

Text-mined interactions from Literome

Mockridge et al., Biochem Biophys Res Commun 2000 (Myocardial Ischemia) : SI/R stimulated Akt activation was inhibited by the phosphatidylinositol 3-kinase (PI3-K) inhibitor wortmannin, the tyrosine kinase inhibitor genistein and the Src tyrosine kinase inhibitor PP2 , indicating a requirement for tyrosine kinase activity in Akt activation
Endo et al., Exp Hematol 2001 : PP2 also inhibited SCF induced phosphorylation of Akt
Haynes et al., J Biol Chem 2003 : Consistent with these results, PP2 blocked 17beta-estradiol induced Akt phosphorylation but did not inhibit NO release from cells transduced with a constitutively active Akt
Roberts et al., Br J Pharmacol 2003 : Akt activation was inhibited by the Src tyrosine kinase inhibitor PP2 , and removal of extracellular calcium
Esposito et al., J Biol Chem 2003 : On the contrary, PP2 ( 4-amino-5- ( 4-chlorophenyl ) -7- ( t-butyl ) pyrazole [ 3,4-d ] pyrimidine ), an inhibitor of Src kinase, completely prevents DEM- and H2O2 induced AKT activation but has no effect on the pathway of ERKs
Lei et al., J Biol Chem 2004 : PP1 or PP2 blocked T3-stimulated PKB/Akt phosphorylation at serine 473 and PI3K activity that was activated by an active mutant of Src ; however, wortmannin did not inhibit the T3-stimulated Src kinase activity ... PP1 or PP2 blocked T3-stimulated PKB/Akt phosphorylation at serine 473 and PI3K activity that was activated by an active mutant of Src ; however, wortmannin did not inhibit the T3-stimulated Src kinase activity
Ichiki et al., Biochem Biophys Res Commun 2004 : GM6001, a matrix metalloproteinase inhibitor, and PP2 , a Src family protein kinase inhibitor, suppressed 15-d-PGJ2- and TZDs induced phosphorylation of EGF-R and PDGFbeta-R as well as activation of ERK1/2 and Akt
Jin et al., J Biol Chem 2005 : Gab1 phosphorylation as well as activation of Akt and eNOS by flow was inhibited by the Src kinase inhibitor PP2 ( 4-amino-5- ( 4-chlorophenyl ) -7- ( t-butyl ) pyrazolo [ 3,4-d ] pyrimidine ) and VEGFR2 kinase inhibitors SU1498 and VTI, suggesting that flow mediated Gab1 phosphorylation is Src kinase dependent and VEGFR2 dependent
Suh et al., J Immunol 2005 : Of these, anti-CD45RO inhibited phosphorylation of Hck and Akt, and PP2 inhibited phosphorylation of Hck and Akt
Xu et al., Invest Ophthalmol Vis Sci 2006 : On the other hand, AKT phosphorylation was much more sensitive to PP2 than ERK or EGFR phosphorylation because 3.13 microM PP2 effectively inhibited wound- or HB-EGF induced AKT phosphorylation
Cui et al., J Neurochem 2007 : LY294002, Wortmannin and PP2 also blocked Akt activation
Kim et al., Arch Pharm Res 2008 (Prostatic Neoplasms) : TMS induced activation of protein phosphatase 2A (PP2A) inhibited Akt phosphorylation and p27 ( kip1 ) expression, indicating that PP2A is involved in the induction of p27 ( kip1 ) via Akt inhibition
Sivakumar et al., Int J Oncol 2009 : PP2 just attenuated the phosphorylation in Akt , not through IGF-IR inactivation, leading to apoptosis in SLUG-MDCK cells
Lee et al., Cell Mol Life Sci 2009 : Galectin-1 induced phospho-Akt and -mTOR was inhibited by PP2 , ERas siRNA, caveolin-1 siRNA and Mbeta-CD
Xiao et al., Cell Death Differ 2010 : Finally, overexpression of PP-1alpha or PP-1beta but not PP-1gamma, PP-2Aalpha or PP-2Abeta results in attenuated phosphorylation of AKT at Thr-450
La Sala et al., Exp Cell Res 2010 : While the ER antagonist ICI182780 was able to abolish these effects, AKT phosphorylation induced by E2 was also inhibited by the PI3K inhibitor LY294002 and the SRC family inhibitor PP2
Yang et al., Eur J Pharmacol 2010 : Both plumbagin stimulated ERK1/2 and Akt activities were attenuated by PP2 , a Src inhibitor
Zhang et al., J Cell Biochem 2013 : PP2 reduced the glutamate release from BDNF stimulated cortical neurons ( P? < ?0.05 ) and inhibited the phosphorylation levels of TrkB and PLC-?1 ( P? < ?0.05 ). However, PP2 had no effect on the phosphorylation levels of Erk1/2 or Akt ( P? > ?0.05 )
Yang et al., PloS one 2013 : The AGEs stimulated Akt activation was blocked by a PI3-kinase inhibitor LY 294002, Src inhibitor PP2 , an antioxidant NAC, superoxide scavenger Tiron, or nicotinamide adenine dinucleotide phosphate ( NAD ( P ) H ) oxidase inhibitor DPI, suggesting the involvement of Src and NAD ( P ) H oxidase in the activation of PI3-kinase-Akt pathway by AGEs