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DDIT3 — IL6

Text-mined interactions from Literome

Hattori et al., J Interferon Cytokine Res 2001 (Melanoma) : The experiments using CHOP muteins revealed that dimerization ability - but not p38 MAPK dependent phosphorylation or DNA binding activity - is important for the IL-6 inducing activity of CHOP
Hattori et al., FEBS Lett 2003 : These results indicate that CHOP plays an important role in IL-6 production without binding to its promoter, probably by trapping protein ( s ) such as LIP, which would otherwise inhibit IL-6 transcription
Göransson et al., Int J Cancer 2005 (Fibrosarcoma...) : Knockdown experiments using siRNA against CEBPB transcripts showed that the effect of FUS-DDIT3 on IL6 expression is C/EBP beta dependent
Gao et al., Mol Immunol 2009 : Furthermore, ectopic expression of C/EBPzeta inhibited C/EBPbeta dependent IL-6 expression from both the endogenous IL-6 gene and an IL-6 promoter-reporter
Nicoletti-Carvalho et al., J Endocrinol 2010 (Insulinoma...) : In this way, CHOP and ATF4 might mediate PA-induced TRIB3 expression and, by extension, the suppression of IL6 activation of pro-survival kinase AKT