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ARG2 — STAT3
Text-mined interactions from Literome
Sato et al., Biochem Biophys Res Commun 2005
(Carcinoma, Hepatocellular) :
These data demonstrate that
Arg-214/215 are
involved in CRM1 mediated STAT3 nuclear export and the regulation of
STAT3 activity
Liu et al., J Immunol 2008
(Disease Models, Animal...) :
Macrophages in which SOCS3 was knocked down by short interfering RNA responded to IFN-gamma and LPS very differently : they had enhanced
STAT3 activity ;
induction of macrophage mannose receptor,
arginase and SOCS1 ; restoration of IL-4 responsiveness that is inhibited in M1 macrophages ; and decreased synthesis of inflammatory mediators ( NO and IL-6 ) and costimulatory molecule CD86, demonstrating that SOCS3 is essential for M1 activation
Cardó-Vila et al., PloS one 2008
(Neoplasms) :
Here we design and validate in-tandem binding assays, site directed mutagenesis and NMR spectroscopy to show ( i ) the peptide mimics a receptor binding site within IL-11, ( ii ) the binding of CGRRAGGSC to the IL-11R alpha is functionally relevant, ( iii )
Arg4 and Ser8 are the key residues mediating the interaction, and ( iv ) the IL-11-like motif
induces cell proliferation through
STAT3 activation