Gene interactions and pathways from curated databases and text-mining

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ACE — IGF1

Text-mined interactions from Literome

Nilsson et al., Am J Physiol Regul Integr Comp Physiol 2000 (Abnormalities, Drug-Induced) : Ongoing ACE inhibition suppressed the medullary IGF-I mRNA expression and altered the local distribution of both IGF-I and GHR
van Eickels et al., Br J Pharmacol 2000 : IGF-I induced expression was completely inhibited by ACE inhibition or AT(1) receptor blockade ... The IGF-I induced overexpression of the IGF-IR was reduced by ACE inhibition with moexiprilat ( 10 ( -7 ) M ) by 79+/-7 % and by AT(1) receptor blockade with CV11974 ( 10 ( -7 ) M ) by 79+/-5 %
Díez et al., J Hypertens Suppl 1994 (Hypertension...) : To determine whether the effect of angiotensin converting enzyme (ACE) inhibitors on left ventricular hypertrophy in patients with essential hypertension is related to ACE inhibitor effects on IGF-1 levels ... All three ACE inhibitors caused similar reductions in IGF-1 levels, the left ventricular mass index and blood pressure after the treatment period