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ACE — IGF1
Text-mined interactions from Literome
Nilsson et al., Am J Physiol Regul Integr Comp Physiol 2000
(Abnormalities, Drug-Induced) :
Ongoing
ACE inhibition
suppressed the medullary
IGF-I mRNA expression and altered the local distribution of both IGF-I and GHR
van Eickels et al., Br J Pharmacol 2000
:
IGF-I induced expression was completely
inhibited by
ACE inhibition or AT(1) receptor blockade ... The IGF-I induced overexpression of the
IGF-IR was
reduced by
ACE inhibition with moexiprilat ( 10 ( -7 ) M ) by 79+/-7 % and by AT(1) receptor blockade with CV11974 ( 10 ( -7 ) M ) by 79+/-5 %
Díez et al., J Hypertens Suppl 1994
(Hypertension...) :
To determine whether the effect of angiotensin converting enzyme (ACE) inhibitors on left ventricular hypertrophy in patients with essential hypertension is related to
ACE inhibitor
effects on
IGF-1 levels ... All three
ACE inhibitors
caused similar reductions in
IGF-1 levels, the left ventricular mass index and blood pressure after the treatment period