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CASP7 — CDK5
Text-mined interactions from Literome
Sandal et al., J Biol Chem 2002
(Leukemia, Promyelocytic, Acute) :
The inhibition of
CDK5 prevented the cleavage of
pro-caspase-3 in cAMP treated cells
Weishaupt et al., Mol Cell Neurosci 2003
(Brain Ischemia...) :
We find that blocking
CDK5 activity, but not
caspase inhibition , protects mitochondrial integrity of lesioned neurons
Sohn et al., Cancer Res 2006
:
p21 blocks irradiation induced apoptosis downstream of mitochondria by inhibition of
cyclin dependent kinase mediated
caspase-9 activation
Huang et al., J Biochem 2009
:
In addition, the inhibition of
Cdk5 prevented Bcl-2 phosphorylation and
enhanced H ( 2 ) O ( 2 ) -induced
caspase-3 activation as well as subsequent DNA fragmentation
Kuo et al., Chin J Physiol 2009
(Uterine Cervical Neoplasms) :
In addition, our results also indicated that
Cdk5 activity was
involved in RA-induced HeLa apoptosis by detecting cleavages of
caspase-3 and its substrate, PARP ( poly ( ADP-ribose ) polymerases ) Interestingly, the nuclear localizations of Cdk5 and p35 proteins were increased by RA treatment, which, again, suggests the involvement of Cdk5 and p35 in RA-induced apoptotic effects
Yang et al., Mol Med Report 2010
:
The expression of cyclin D1
, cyclin dependent kinase 4 (CDK4), Bcl-2, Bcl-xL and
the activation
of caspase-3 were examined by Western blotting