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DNMT1 — DNMT3A

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: DNMT1 — DNMT3A Kim et al., EMBO J 2002*
• IRef Bind_translation Interaction: DNMT1 — DNMT3A (affinity chromatography technology) Kim et al., EMBO J 2002*
• IRef Bind_translation Interaction: DNMT1 — DNMT3A (coimmunoprecipitation) Kim et al., EMBO J 2002*
• IRef Biogrid Interaction: DNMT1 — DNMT3A (physical association, affinity chromatography technology) Rigbolt et al., Science signaling 2011
• IRef Biogrid Interaction: DNMT1 — DNMT3A (direct interaction, pull down) Kim et al., EMBO J 2002*
• IRef Biogrid Interaction: DNMT1 — DNMT3A (physical association, affinity chromatography technology) Kim et al., EMBO J 2002*
• IRef Hprd Interaction: DNMT3A — DNMT1 (in vitro) Kim et al., EMBO J 2002*
• IRef Hprd Interaction: DNMT3A — DNMT1 (in vivo) Kim et al., EMBO J 2002*
• IRef Intact Interaction: Complex of DNMT3A-DNMT3B-EZH2-DNMT1 (association, anti bait coimmunoprecipitation) Viré et al., Nature 2006
• IRef Intact Interaction: Complex of EED-DNMT3B-DNMT3A-DNMT1 (association, anti bait coimmunoprecipitation) Viré et al., Nature 2006
• IRef Intact Interaction: Complex of DNMT1-UHRF1-DNMT3A (physical association, anti tag coimmunoprecipitation) Meilinger et al., EMBO Rep 2009*
• IRef Intact Interaction: Complex of DNMT3A-NRIP1-DNMT1-DNMT3B-NRIP1-DNMT3A-DNMT1-DNMT3B (association, pull down) Kiskinis et al., EMBO J 2007*
• IRef Ophid Interaction: DNMT1 — DNMT3A (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Vinken et al., Toxicol In Vitro 2010 : Similar to the hepatic in vivo situation, DNMT1 , DNMT2 and DNMT3b could not be detected , whereas relatively high levels of DNMT3a protein were observed in the in vitro setting, as studied by immunoblotting
Pan et al., PloS one 2013 : DNMT1 and DNMT3a expressions were significantly downregulated and the global DNMT activity was inhibited when treated with 10 ng/mL of TGF-ß1 for 48 h. TGF-ß1 treatment resulted in a significant reduction of the DNA methylation percentage across multiple CpG sites in the rat COL1A1 promoter