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CDK5 — MDM2

Text-mined interactions from Literome

Lee et al., J Cell Sci 2007 : Cdk5 mediates disruption of the interaction between p53 and Hdm2 ( also known as Mdm2 ), and prevents Hdm2 induced p53 ubiquitylation and downregulation
Bianchetta et al., J Neurosci 2011 : Here we demonstrate that genetic or pharmacological reduction of Cdk5 activity increases the interaction of Mdm2 with PSD-95 and enhances PSD-95 ubiquitination without affecting PSD-95 protein levels in vivo in mice, suggesting a nonproteolytic function of ubiquitinated PSD-95 at synapses ... This interaction is increased by genetic reduction of Cdk5 activity or NMDA receptor stimulation and is dependent on Mdm2