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CD4 — FYN

Pathways - manually collected, often from reviews:

• NCI Pathway Database TCR signaling in naïve CD4+ T cells: Fyn (FYN) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, activates)
  Kwon et al., EMBO J 2005, Han et al., Science 1998, Michel et al., J Biol Chem 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: Fyn (FYN) → TCR/CD3/MHC II/CD4/Fyn complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-FYN-CD247) (modification, collaborate)
  van't Hof et al., J Cell Biol 1999, Samelson et al., Proc Natl Acad Sci U S A 1990
  Evidence: assay, physical interaction, other species
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: Fyn (FYN) → TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4) (modification, collaborate)
  van't Hof et al., J Cell Biol 1999, Samelson et al., Proc Natl Acad Sci U S A 1990
  Evidence: assay, physical interaction, other species
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/Fyn complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-FYN-CD247) → TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4) (modification, collaborate)
  van't Hof et al., J Cell Biol 1999, Samelson et al., Proc Natl Acad Sci U S A 1990
  Evidence: assay, physical interaction, other species
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: SHP2 (PTPN11) → TCR/CD3/MHC II/CD4/Fyn complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-FYN-CD247) (modification, inhibits)
  Kwon et al., EMBO J 2005, da Silva et al., Proc Natl Acad Sci U S A 1997
  Evidence: mutant phenotype, physical interaction, other species

Text-mined interactions from Literome

Mamchak et al., J Immunol 2008 : Fyn-deficient mice have greatly decreased numbers of NKT cells and have thymocytes and T cells with compromised responses following Ab crosslinking of their TCRs. Herein we have addressed the role of Fyn in peptide/MHC class II-induced CD4 ( + ) T cell responses
Baldari et al., Eur J Immunol 1995 (Second Messenger Systems) : Here, we report that cross linking of CD4 on the surface of Jurkat cells using monoclonal antibodies results in activation of the CD3 associated kinase p59fyn ... Co-cross linking of CD4 and CD3 results in synergistic activation of p59fyn ... The p59fyn kinase is also hyperactive in a Jurkat cell line stably transfected with a constitutively active p56lck mutant, indicating that p56lck mediates CD4 activation of p59fyn
Raab et al., Biochem Biophys Res Commun 1996 : Ligation of the T cell receptor complex and CD4 leads to activation of the protein tyrosine kinases p56lck and p59fyn resulting in phosphorylation of TcR zeta chain and the recruitment of ZAP-70