Fowlkes et al., J Immunol 2002
:
In theory, expressing a constitutively activated form of Notch in CD4 ( + ) CD8 ( + ) thymocytes could provide clues about the normal role of Notch in developing CD4 and CD8 T cells
Alam et al., Proc Natl Acad Sci U S A 2010
(Hepatitis, Animal) :
Notch mediated stimulation of CD4 ( + ) T cells increased the production of IL-22 even in the absence of STAT3
Hunt et al., Mol Cell Biol 2011
:
This defect was recapitulated in vitro as Mtg16 ( -/- ) Lineage ( - ) /Sca1 ( + ) /c-Kit ( + ) ( LSK ) cells of the bone marrow or DN1 cells of the thymus failed to produce CD4 ( + ) /CD8 ( + ) cells in response to a Notch signal