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HLA-DRB1 — TLR4

Text-mined interactions from Literome

Olson et al., J Immunol 2004 : In addition, TLR stimulation activated up-regulation of MHC class II and costimulatory molecules, enabling the microglia to efficiently present myelin Ags to CD4+ T cells
Tang et al., PloS one 2012 : Our findings suggest that in RAW 264.7 cells ( 1 ) IFN-? provides a condition for lower concentrations of SEA to attenuate MHC class II expression ; ( 2 ) SEA attenuated IFN-? induced MHC class II expression and the IL-10 and IL-6 production is mediated at least partly by the interaction of SEA with TLR4 ; and ( 3 ) SEA attenuated IFN-? induced MHC class II expression at the transcriptional level